Congenital mesoblastic nephroma is characterised by kinase mutations including EGFR internal tandem duplications, the ETV6-NTRK3 fusion, and the rare KLHL7-BRAF fusion.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Congenital mesoblastic nephroma (CMN) is histologically classified into classic, cellular and mixed subtypes. The aims of this study were to characterise the clinical, pathological and molecular features of a series of CMNs, and to determine the utility of pan-Trk and epidermal growth factor receptor (EGFR) immunohistochemistry as surrogate markers for NTRK gene fusions and EGFR internal tandem duplications (ITDs).

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Histopathology

Title: Histopathology

Publisher: Wiley

ISSN (Electronic): 1365-2559

ISSN (Print): 0309-0167

Publication date (Electronic): Oct 2020

Volume: 77

Issue: 4

Affiliations

[1 ] Department of Pathology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province, China.

[2 ] Department of Pathology, Shanghai Children's Medical Centre, Shanghai, China.

[3 ] Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.

[4 ] Lady Ridgeway Hospital for Children, Colombo, Sri Lanka.

[5 ] Department of Paediatric Surgery, KK Women's and Children's Hospital.

[6 ] Duke-NUS Medical School, Singapore.

Article

DOI: 10.1111/his.14194

PubMed ID: 32590884

SO-VID: 4e764357-6360-4d8a-84ce-cfc8e3abbcc2

History

Keywords: EGFR immunohistochemistry,EGFR internal tandem duplication,KLHL7-BRAF gene fusion,congenital mesoblastic nephroma,pan-Trk immunohistochemistry

Data availability:

Keywords: EGFR immunohistochemistry, EGFR internal tandem duplication, KLHL7-BRAF gene fusion, congenital mesoblastic nephroma, pan-Trk immunohistochemistry

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Cited by 9

See all cited by