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      Evaluation of the Effect of Distant Cold Stimulation on Pain During Palatal Injection: A Randomized Split-Mouth Study

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      1 , , 1 , 1 , 2 , 3
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      Cureus
      Cureus
      palatal injection, pain, local anesthesia, cold, cryotherapy

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          Abstract

          Objective

          Delivery of a robust local anesthetic injection aids in the successful management of all patients' fears, anxieties, and discomfort during dental treatments. The most expected or frightening stimuli in the dental operatory are local anesthetic injections. The objective of this trial was to study the analgesic efficacy of distant cold stimulation in relieving injection pain from the greater palatine nerve block. Before receiving local anesthetic injections, employing cryotherapy by using an ice bath changes the pain perceptions and also increases the pain threshold.

          Purpose

          The aim of this study is to evaluate the effect of distant cold stimulation on palatal injection pain using an ice-cold bath.

          Method

          This was a randomized, controlled trial conducted at an oral and maxillofacial surgery department. A split-mouth technique was employed for the study, in which patients requiring bilateral greater palatine nerve block for any dental procedures were included. The bilateral greater palatine nerve block was given one at a time, separated by an interval of three days. The inclusion criteria for this study were no history of drug allergy and an extraction site free of any active infection. There were 28 participants in this experimental study. Two groups were randomly created from this research sample: group A (palatal injection with distant cold stimulation) and group B (palatal injection without distant cold stimulation). In group A, the patient was asked to put his or her hand of the same side as the palatal injection in an ice-cold bath till the time patient could tolerate it; immediately after the patient removed his hand, the greater palatine nerve block was given, and the patient was assessed for the injection pain. In group B, the patient was directly given the greater palatine nerve block without any distant cold stimulation. The time interval between the two extractions/dental procedures was three days. Outcomes of interest were pain severity with and without distant cold stimulation which were assessed using a Visual Analogue Scale (VAS) pain scale, and a comparison was made between the two groups.

          Results

          As per our study, in terms of pain, there was a statistically significant difference between the two interventions at all time points. Patients in group A had a lower score on the VAS pain scale as compared to group B. The standard deviation (STD) for group A was 0.81, and the standard deviation for group B was 0.92. P value was derived to be P < 0.001, which is suggestive of a significant difference between the pain scores of both groups.

          Conclusion

          Hence, we conclude that the use of distant cryotherapy as an adjunct is an effective way to reduce pain perception and increase pain threshold. This technique is comparatively simple, painless, and easy for the surgeon and for apprehensive patients, and it offers a fair cost solution for the suffering often associated with dental procedures requiring local anesthetic injections.

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          Most cited references20

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          The effect of pre-cooling the injection site on pediatric pain perception during the administration of local anesthesia.

          The aim of the study was to evaluate the effect of cooling the soft tissue of injection sites on the pain perceptions of pediatric patients during the administration of local anesthesia for routine dental procedures.
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            Effectiveness of new vibration delivery system on pain associated with injection of local anesthesia in children.

            Pain is highly subjective and it is neurologically proven that stimulation of larger diameter fibers - e.g., using appropriate coldness, warmth, rubbing, pressure or vibration - can close the neural "gate" so that the central perception of itch and pain is reduced. This fact is based upon "gate control" theory of Melzack and Wall. The present study was carried out to investigate the effects of vibration stimuli on pain experienced during local anesthetic injections.
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              Conduction failure in myelinated and non-myelinated axons at low temperatures.

              1. The effects of low temperature on conduction in single myelinated and non-myelinated axons of the feline saphenous nerve were examined and compared. Nerves were cooled by a conventional thermode, but thermal gradients were minimized by an insulating layer of agar-saline gel over the nerve and the face of the thermode.2. The mean blocking temperature of thirty-one non-myelinated axons, 2.7 degrees C, was significantly lower than that of 111 myelinated axons, 7.2 degrees C. No evidence for a differential block of myelinated axons according to their normal conduction velocity could be demonstrated.3. Reductions in the proportional conduction velocities of both myelinated and non-myelinated axons were nearly identical between 17 and 37 degrees C. However, below 17 degrees C the rate at which the proportional conduction velocity of the non-myelinated axons fell during cooling was significantly less than for the myelinated axons and was sufficient to account for their lower blocking temperatures. As a result, critical minimum conduction velocities were reached at higher temperatures in myelinated axons than in non-myelinated axons.4. The conduction velocity of successive impulses in a train slowed progressively to a constant value which depended on the frequency of stimulation. Consequently, the early impulses were separated by intervals that exceeded those between stimuli and were not affected by temperatures that blocked later impulses. The pattern of block was consistent with an increasing refractoriness of the axons as the temperature fell.5. The maximal frequency of discharge that myelinated axons could carry at temperatures between normal and 12 degrees C was related directly to fibre size. Non-myelinated axons could conduct low frequency trains of impulses at temperatures that blocked such activity in myelinated axons. In all axons, high frequency trains of impulses could be completely blocked at temperatures which permitted lower frequency trains to pass uninterrupted.6. Hysteresis in the blocking temperatures of axons was related to the hysteresis in their conduction velocities.
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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                18 April 2023
                April 2023
                : 15
                : 4
                : e37749
                Affiliations
                [1 ] Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune, Pune, IND
                [2 ] Oral Medicine and Radiology, Bharati Vidyapeeth Dental College and Hospital, Pune, Pune, IND
                [3 ] Orthodontics and Dentofacial Orthopaedics, Bharati Vidyapeeth Dental College and Hospital, Pune, Pune, IND
                Author notes
                Article
                10.7759/cureus.37749
                10193191
                4d1543e0-1f9b-40cf-b051-3fa7f77bdeb7
                Copyright © 2023, Lakhani et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 18 April 2023
                Categories
                Anesthesiology
                Trauma
                Dentistry

                palatal injection,pain,local anesthesia,cold,cryotherapy
                palatal injection, pain, local anesthesia, cold, cryotherapy

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