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      STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.

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          Abstract

          Streptozotocin (STZ) treatment, a common model for inducing diabetes in rodent models, induces thermal hyperalgesia and neuronal toxicity independently of hyperglycemia by oxidizing and activating TRPA1 and TRPV1. Following treatment with STZ, CD45(+) immune cells were found to be depleted in sciatic nerve (SN) and DRG in mice, prior to hyperglycemia. Macrophages were also lost in DRG and NFκB-p65-activation was increased in SN macrophages. Immune cells were significantly reduced in both SN and DRG up to three weeks, post-treatment. Loss of PNS-resident macrophages in response to STZ-mediated toxicity may affect the regenerative capacity of the nerve in response to further injury caused by diabetes.

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          Author and article information

          Journal
          J. Neuroimmunol.
          Journal of neuroimmunology
          Elsevier BV
          1872-8421
          0165-5728
          May 15 2017
          : 306
          Affiliations
          [1 ] Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, Heidelberg, Germany.
          [2 ] Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, Heidelberg, Germany; Institute for Diabetes and Cancer IDC Helmholtz Center Munich, Germany & Joint Heidelberg-IDC Translational Diabetes Program, Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
          [3 ] Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, Heidelberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address: Thomas.Fleming@med.uni-heidelberg.de.
          Article
          S0165-5728(16)30248-X
          10.1016/j.jneuroim.2017.03.008
          28385191
          4c4b700c-0be5-4957-98c6-c2f61098923f
          History

          Diabetic neuropathy,Experimental diabetes,Macrophage,Neurotoxicity

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