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      Exploring multimorbidity clusters in relation to healthcare use and its impact on self-rated health among older people in India

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      PLOS Global Public Health
      Public Library of Science

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          Abstract

          The conventional definition of multimorbidity may not address the complex treatment needs resulting from interactions between multiple conditions, impacting self-rated health (SRH). In India, there is limited research on healthcare use and SRH considering diverse disease combinations in individuals with multimorbidity. This study aims to identify multimorbidity clusters related to healthcare use and determine if it improves the self-rated health of individuals in different clusters. This study extracted information from cross-sectional data of the first wave of the Longitudinal Ageing Study in India (LASI), conducted in 2017–18. The study participants were 31,373 people aged ≥ 60 years. A total of nineteen chronic diseases were incorporated to identify the multimorbidity clusters using latent class analysis (LCA) in the study. Multivariable logistic regression was used to examine the association between identified clusters and healthcare use. A propensity score matching (PSM) analysis was utilised to further examine the health benefit (i.e., SRH) of using healthcare in each identified cluster. LCA analysis identified five different multimorbidity clusters: relatively healthy’ (68.72%), ‘ metabolic disorder (16.26%), ‘ hypertension-gastrointestinal-musculoskeletal’ (9.02%), ‘ hypertension-gastrointestinal’ (4.07%), ‘ complex multimorbidity’ (1.92%). Older people belonging to the complex multimorbidity [aOR:7.03, 95% CI: 3.54–13.96] and hypertension-gastrointestinal-musculoskeletal [aOR:3.27, 95% CI: 2.74–3.91] clusters were more likely to use healthcare. Using the nearest neighbor matching method, results from PSM analysis demonstrated that healthcare use was significantly associated with a decline in SRH across all multimorbidity clusters. Findings from this study highlight the importance of understanding multimorbidity clusters and their implications for healthcare utilization and patient well-being. Our findings support the creation of clinical practice guidelines (CPGs) focusing on a patient-centric approach to optimize multimorbidity management in older people. Additionally, finding suggest the urgency of inclusion of counseling and therapies for addressing well-being when treating patients with multimorbidity.

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            Deciding on the Number of Classes in Latent Class Analysis and Growth Mixture Modeling: A Monte Carlo Simulation Study

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              Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms

              Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrovascular disease. Common mechanisms, such as upregulation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, and activation of the immune system likely contribute to the close relationship between diabetes and hypertension. In this article we discuss diabetes and hypertension as comorbidities and discuss the pathophysiological features of vascular complications associated with these conditions. We also highlight some vascular mechanisms that predispose to both conditions, focusing on advanced glycation end products, oxidative stress, inflammation, the immune system, and microRNAs. Finally, we provide some insights into current therapies targeting diabetes and cardiovascular complications and introduce some new agents that may have vasoprotective therapeutic potential in diabetes.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Writing – review & editing
                Role: ConceptualizationRole: Writing – original draft
                Role: ConceptualizationRole: Writing – review & editing
                Role: Editor
                Journal
                PLOS Glob Public Health
                PLOS Glob Public Health
                plos
                PLOS Global Public Health
                Public Library of Science (San Francisco, CA USA )
                2767-3375
                28 December 2023
                2023
                : 3
                : 12
                : e0002330
                Affiliations
                [1 ] Centre for Health Services Studies, University of Kent, Kent, England, United Kingdom
                [2 ] Department of Family and Generations, International Institute for Population Sciences, Mumbai, India
                PLOS: Public Library of Science, UNITED STATES
                Author notes

                The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0002-6582-7215
                https://orcid.org/0000-0001-5355-1429
                Article
                PGPH-D-23-01119
                10.1371/journal.pgph.0002330
                10754468
                38153935
                4b38e191-ae87-4658-bee5-e9d74b95688b
                © 2023 Ansari et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 22 June 2023
                : 17 November 2023
                Page count
                Figures: 6, Tables: 5, Pages: 19
                Funding
                The authors received no specific funding for this work.
                Categories
                Research Article
                People and Places
                Geographical Locations
                Asia
                India
                Medicine and Health Sciences
                Medical Conditions
                Metabolic Disorders
                Medicine and Health Sciences
                Health Care
                Health Care Facilities
                Medicine and Health Sciences
                Health Care
                Medicine and Health Sciences
                Endocrinology
                Endocrine Disorders
                Diabetes Mellitus
                Medicine and Health Sciences
                Medical Conditions
                Metabolic Disorders
                Diabetes Mellitus
                Medicine and Health Sciences
                Health Care
                Patients
                Outpatients
                Medicine and Health Sciences
                Health Care
                Patients
                Inpatients
                Medicine and Health Sciences
                Vascular Medicine
                Blood Pressure
                Hypertension
                Custom metadata
                The datasets generated and/or analyzed during the current study are available in the International Institute for Population Sciences (IIPS), Mumbai repository. A reasonable request for data access can be made at https://www.iipsindia.ac.in/content/LASI-data.

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