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Abstract
Using a novel one-step spray-drying process uncoated and Eudragit S 100 coated chitosan-Ca-alginate
microparticles efficiently loaded with budesonide (BDS), with bioadhesive and controlled
release properties in GIT, were prepared. Microparticles were spherical with mean
particle size of 4.05-5.36 microm, narrow unimodal distribution and positive surface
charge. A greater extent of calcium chloride limited the swelling ratio of beads,
while swelling behaviour of coated beads was mainly determined by properties of enteric
coating. Comparing the release profiles of formulations, under different pH conditions,
influence of polymer properties and concentration of cross-linker on the rate and
extent of drug release was evident. Coating has successfully sustained release of
BDS in buffers at pH 2.0 and 6.8, while providing potential for efficient release
of BDS at pH 7.4. Release data kinetics indicated influence of erosion and biodegradation
of polymer matrix on drug release from microparticles. Prepared formulations were
stable for 12 months period at controlled ambient conditions. In conclusion coated
microparticles prepared by one-step spray-drying procedure could be suitable candidates
for oral delivery of BDS with controlled release properties for local treatment of
inflammatory bowel diseases.