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Nanog promotes stem-like traits of glioblastoma cells
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Abstract
<p class="first" id="d4509165e127">Glioblastoma multiforme (GBM) is a highly aggressive
brain tumor with poor progrnosis
and a high recurrence rate after surgery. To this end, we examined the role of Nanog
that is highly expressed in this tumor. NANOG is a transcription factor involved in
the pluripotency of embryonic stem cells (ESCs) and the induction of malignancy in
cancer stem-like cells (CSCs). Bioinformatic analysis revealed that NANOG may be associated
with the development of stem-like traits in GBM. Forced expression of NANOG markedly
increased the expression of cancer stem cell markers and promoted the sphere formation
and migration of GBM cells. Nanog enhanced the expression of SHH which is required
for the maintenance of the positive feedback loop of Hedgehog signaling pathway. Treatment
of GBM cells with SANT-1 and GANT61 significantly reduced the tumor progression. These
data support a view that reduction of Nanog might have therapeutic benefits in GBM.
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