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      Potential role of Chinese medicine nanoparticles to treat coronary artery disease

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          Abstract

          Coronary artery disease (CAD) is a leading cause of death worldwide, while conventional treatments such as percutaneous coronary intervention (PCI) have limitations. This review aims to explore the potential of nanoparticles loaded with Chinese medicine in the treatment of CAD. We conducted a comprehensive literature search to summarize the characteristics of nanovehicle systems, targeting strategies, and administration methods of various nanoparticles containing Chinese medicine for CAD treatment. Nanoparticle-based drug delivery systems, capable of delivering Chinese medicine, offer several advantages, including high targeting efficiency, prolonged half-life, and low systemic toxicity, making them promising for CAD treatment. Overall, nanoparticles containing Chinese medicine present a promising approach for the treatment of CAD.

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          PLGA-based nanoparticles: an overview of biomedical applications.

          Fabienne Danhier, Eduardo Ansorena, Joana Silva … (2012)
          Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers. Among the different polymers developed to formulate polymeric nanoparticles, PLGA has attracted considerable attention due to its attractive properties: (i) biodegradability and biocompatibility, (ii) FDA and European Medicine Agency approval in drug delivery systems for parenteral administration, (iii) well described formulations and methods of production adapted to various types of drugs e.g. hydrophilic or hydrophobic small molecules or macromolecules, (iv) protection of drug from degradation, (v) possibility of sustained release, (vi) possibility to modify surface properties to provide stealthness and/or better interaction with biological materials and (vii) possibility to target nanoparticles to specific organs or cells. This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases. This review focuses on the understanding of specific characteristics exploited by PLGA-based nanoparticles to target a specific organ or tissue or specific cells. Copyright © 2012 Elsevier B.V. All rights reserved.
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            An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

            Mohamed F Attia, Nicolas Anton, Justine Wallyn … (2019)
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              Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine

              Domenico Lombardo, Mikhail Kiselev, Maria Teresa Caccamo (2019)
              The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. Despite the remarkable developments of recent synthetic methodologies, most of all nanocarriers’ action is associated with a number of unwanted side effects that diminish their efficient use in biotechnology and nanomedicine applications. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media.
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                Author and article information

                Contributors
                Qing Liu
                Journal
                Journal ID (nlm-ta): Heliyon
                Journal ID (iso-abbrev): Heliyon
                Title: Heliyon
                Publisher: Elsevier
                ISSN (Electronic): 2405-8440
                Publication date PMC-release: 01 September 2023
                Publication date Collection: September 2023
                Publication date (Electronic): 01 September 2023
                Volume: 9
                Issue: 9
                Electronic Location Identifier: e19766
                Affiliations
                [1]The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong, 510120, China
                Author notes
                [∗ ]Corresponding author. The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, # 111 Dade Road, Yuexiu District, Guangzhou, Guangdong, China. 851757626@ 123456qq.com
                Article
                Publisher Item ID: S2405-8440(23)06974-8 Publisher ID: e19766
                DOI: 10.1016/j.heliyon.2023.e19766
                PMC ID: 10559060
                PubMed ID: 37809499
                SO-VID: 44dafda2-3d6d-422f-b006-f2464b3e31f6
                Copyright © © 2023 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 25 January 2023
                Date revision received : 29 August 2023
                Date accepted : 31 August 2023
                Categories
                Subject: Review Article

                Keywords: nanoparticle,coronary artery disease,chinese medicine,drug delivery system,targeting strategy
                Data availability:
                Keywords: nanoparticle, coronary artery disease, chinese medicine, drug delivery system, targeting strategy

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