Contributors
Xin Yin: Role: InvestigationRole: Methodology
Guohua Deng: Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: Validation
Xianying Zeng: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Validation
Pengfei Cui: Role: Investigation
Yujie Hou: Role: Investigation
Yanjing Liu: Role: Investigation
Jingzhen Fang: Role: Investigation
Shuxin Pan: Role: Investigation
Dongxue Wang: Role: Investigation
Xiaohan Chen: Role: Investigation
Yaping Zhang: Role: Investigation
Xiurong Wang: Role: Resources
Guobin Tian: Role: Funding acquisitionRole: Investigation
Yanbing Li: Role: Funding acquisitionRole: Investigation
Yan Chen: Role: Funding acquisitionRole: Investigation
Liling Liu: Role: Investigation
Yasuo Suzuki:
ORCID: https://orcid.org/0000-0003-3518-5642
Role: Resources
Yuntao Guan: Role: Investigation
Chengjun Li:
ORCID: https://orcid.org/0000-0001-8460-8619
Role: Investigation
Jianzhong Shi:
ORCID: https://orcid.org/0000-0003-4580-9455
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: Writing – original draft
Hualan Chen:
ORCID: https://orcid.org/0000-0001-8910-898X
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
Project administrationRole: SupervisionRole: ValidationRole: Writing – original draftRole:
Writing – review & editing
Alexander Bukreyev: Role: Editor
Journal
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
27
April
2021
Publication date Collection:
April
2021
Volume: 17
Issue: 4
Electronic Location Identifier: e1009561
Affiliations
[1
]
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute,
CAAS, Harbin, People’s Republic of China
[2
]
College of Life and Health Sciences, Chubu University, Aichi, Japan
University of Texas Medical Branch / Galveston National Laboratory, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PPATHOGENS-D-21-00387
DOI: 10.1371/journal.ppat.1009561
PMC ID: 8104392
PubMed ID: 33905456
SO-VID: 441486ac-95f2-49db-a966-cf85759ef395
Copyright © © 2021 Yin et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 19
February
2021
Date
accepted
: 14
April
2021
Page count
Figures: 6,
Tables: 2,
Pages: 19
Funding
Funded by: The National Key R&D Program of China
Award ID: 2016YFD0500201
Award Recipient
:
Guohua Deng
Funded by: The National Key R&D Program of China
Award ID: 2016YFD0500203
Award Recipient
:
ORCID: https://orcid.org/0000-0001-8910-898X
Hualan Chen
Funded by: The National Natural Science Foundation of China
Award ID: 31521005
Award Recipient
:
ORCID: https://orcid.org/0000-0001-8910-898X
Hualan Chen
Funded by: The China Agriculture Research System
Award ID: CARS-41-G12
Award Recipient
:
Guobin Tian
Funded by: The Central Public-interest Scientific Institution Basal Research Fund
Award ID: NO.1610302017001
Award Recipient
:
Yan Chen
Funded by: Natural Science Foundation of Heilongjiang Province of China
Award ID: ZD2018007
Award Recipient
:
Yanbing Li
This work was supported by the National Key R&D Program of China (2016YFD0500201(GD),
2016YFD0500203(HC)), the National Natural Science Foundation of China (31521005) (HC),
the China Agriculture Research System (CARS-41-G12) (GT), the Central Public-interest
Scientific Institution Basal Research Fund (NO.1610302017001) (YC), and Natural Science
Foundation of Heilongjiang Province of China (ZD2018007) (YL). The funders had no
role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H7N9
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H7N9
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H7N9
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H7N9
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Fowl
Subject:
Gamefowl
Subject:
Chickens
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Fowl
Subject:
Gamefowl
Subject:
Chickens
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Poultry
Subject:
Chickens
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Poultry
Subject:
Chickens
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Infectious Disease Control
Subject:
Vaccines
Subject:
Viral Vaccines
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Vaccines
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Poultry
Subject:
Ducks
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Poultry
Subject:
Ducks
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Fowl
Subject:
Waterfowl
Subject:
Ducks
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Fowl
Subject:
Waterfowl
Subject:
Ducks
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Poultry
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Poultry
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Birds
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antigens
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