Enhanced oxidase/peroxidase-like activities of aptamer conjugated MoS <sub>2</sub>/PtCu nanocomposites and their biosensing application

Author(s): Cui Qi ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Shuangfei Cai ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Xinhuan Wang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Jingying Li ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Zheng Lian ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Shanshan Sun ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Rong Yang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Chen Wang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵

Publication date (Electronic): 2016

Journal: RSC Advances

Publisher: Royal Society of Chemistry (RSC)

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Abstract

Taking advantage of bimetallic alloy nanoparticles and MoS ₂ nanosheets, a colorimetric aptasensor was developed for MUC1 overexpressed cancer cell detection.

Abstract

Hybrid composite materials are particularly useful and offer great opportunities for catalysis due to their multifunctionalities. Taking advantage of the high catalytic properties of bimetallic alloy nanoparticles, the large specific surface area and co-catalytic function of MoS ₂ nanosheets, we prepare a novel MoS ₂/PtCu nanocomposite with intrinsic high oxidase- and peroxidase-like activity. The preparation of MoS ₂/PtCu nanocomposites does not require organic solvents or high temperature. The introduction of single-layer MoS ₂ nanosheets not only improves porous PtCu nanoparticles with a fine dispersion, but also readily incorporates recognition elements. As a mimic oxidase, the independence of hydrogen peroxide shows the good biocompatibility of MoS ₂/PtCu for promising bioapplications. On the basis of oxidase-like activity, a novel colorimetric aptasensor (apt-MoS ₂/PtCu) was developed and its application in the colorimetric detection of cancer cells with different MUC1-protein densities was demonstrated. The as-prepared apt-MoS ₂/PtCu shows good sensitivity and selectivity to targeting cells. The proposed strategy will facilitate the utilization of MoS ₂-based nanocomposites with high oxidase/peroxidase activities in biotechnology, biocatalysis etc.

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Most cited references 62

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Two-dimensional materials are attractive for use in next-generation nanoelectronic devices because, compared to one-dimensional materials, it is relatively easy to fabricate complex structures from them. The most widely studied two-dimensional material is graphene, both because of its rich physics and its high mobility. However, pristine graphene does not have a bandgap, a property that is essential for many applications, including transistors. Engineering a graphene bandgap increases fabrication complexity and either reduces mobilities to the level of strained silicon films or requires high voltages. Although single layers of MoS(2) have a large intrinsic bandgap of 1.8 eV (ref. 16), previously reported mobilities in the 0.5-3 cm(2) V(-1) s(-1) range are too low for practical devices. Here, we use a halfnium oxide gate dielectric to demonstrate a room-temperature single-layer MoS(2) mobility of at least 200 cm(2) V(-1) s(-1), similar to that of graphene nanoribbons, and demonstrate transistors with room-temperature current on/off ratios of 1 × 10(8) and ultralow standby power dissipation. Because monolayer MoS(2) has a direct bandgap, it can be used to construct interband tunnel FETs, which offer lower power consumption than classical transistors. Monolayer MoS(2) could also complement graphene in applications that require thin transparent semiconductors, such as optoelectronics and energy harvesting.

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Author and article information

Journal

Journal ID (publisher-id): RSCACL

Title: RSC Advances

Abbreviated Title: RSC Adv.

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 2046-2069

Publication date Created: 2016

Publication date (Electronic): 2016

Volume: 6

Issue: 60

Pages: 54949-54955

Affiliations

[1 ]CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety

[2 ]CAS Center for Excellence in Nanoscience

[3 ]National Center for Nanoscience and Technology

[4 ]Beijing

[5 ]PR China

Article

DOI: 10.1039/C6RA03507H

SO-VID: 43368614-beaa-4a00-a576-9f82c15815c4

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