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Safety and immunogenicity of an intranasal Shigella flexneri 2a Invaplex 50 vaccine.
Mark S Riddle
1 ,
Robert W Kaminski ,
Carlos Williams ,
Chad Porter ,
Shahida Baqar ,
Alexis Kordis ,
Theron Gilliland ,
Joyce Lapa ,
Melissa Coughlin ,
Chris Soltis ,
Erica Jones ,
Jackie Saunders ,
Paul B Keiser ,
Ryan T Ranallo ,
Robert Gormley ,
Michael Nelson ,
K Ross Turbyfill ,
David Tribble ,
Edwin V Oaks
Sep 16 2011
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Abstract
Shigella flexneri 2a lipopolysaccharide 50 is a nasally delivered subunit vaccine consisting of a macromolecular complex composed of LPS, IpaB, IpaC and IpaD. The current study examined vaccine safety and immunogenicity across a dose range and the clinical performance of a new intranasal delivery device.
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