For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
Article has an altmetric score of 4
81
references
 Top references
cited by
18
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      931
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Neurological manifestations in COVID-19: A narrative review

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          COVID-19, a respiratory viral infection, has affected more than 10 million individuals worldwide. Common symptoms include fever, dry cough, fatigue and shortness of breath. Some patients show neurological manifestations such as headache, dizziness, cerebrovascular disease, peripheral nerve and muscle symptoms and smell and taste impairment. In previous studies, SARS-CoV-1 and MERS-CoV were found to affect the nervous system. Given the high similarity between SARS-CoV-1 and SARS-CoV-2, effects on the nervous system by SARS-CoV-2 are a possibility. We have outlined the common neurological manifestations in COVID-19 (information are up-to-date as of June 2020) and discussed the possible pathogenetic mechanisms and management options.

          Related collections

          Most cited references81

          • Record: found
          • Abstract: found
          • Article: found

          Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

          Dawei Wang, Bo Hu, Fangfang Zhu … (2020)
          In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
          Article 0 comments Cited 11148 times – based on 0 reviews     Review now
          Article has an altmetric score of 6253
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

            Ling Mao, Huijuan Jin, Mengdie Wang … (2020)
            The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. However, to our knowledge, it has not been reported that patients with COVID-19 had any neurologic manifestations.
            Article 0 comments Cited 3390 times – based on 0 reviews     Review now
            Article has an altmetric score of 3614
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Dysregulation of immune response in patients with COVID-19 in Wuhan, China

              Chuan Qin, Luoqi Zhou, Ziwei Hu … (2020)
              Abstract Background In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China. Methods Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February 12, 2020, were collected and analyzed. The data of laboratory examinations, including peripheral lymphocyte subsets, were analyzed and compared between severe and non-severe patients. Results Of the 452 patients with COVID-19 recruited, 286 were diagnosed as severe infection. The median age was 58 years and 235 were male. The most common symptoms were fever, shortness of breath, expectoration, fatigue, dry cough and myalgia. Severe cases tend to have lower lymphocytes counts, higher leukocytes counts and neutrophil-lymphocyte-ratio (NLR), as well as lower percentages of monocytes, eosinophils, and basophils. Most of severe cases demonstrated elevated levels of infection-related biomarkers and inflammatory cytokines. The number of T cells significantly decreased, and more hampered in severe cases. Both helper T cells and suppressor T cells in patients with COVID-19 were below normal levels, and lower level of helper T cells in severe group. The percentage of naïve helper T cells increased and memory helper T cells decreased in severe cases. Patients with COVID-19 also have lower level of regulatory T cells, and more obviously damaged in severe cases. Conclusions The novel coronavirus might mainly act on lymphocytes, especially T lymphocytes. Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19.
              Article 0 comments Cited 2399 times – based on 0 reviews     Review now
              Article has an altmetric score of 398
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): SAGE Open Med
                Journal ID (iso-abbrev): SAGE Open Med
                Journal ID (publisher-id): SMO
                Journal ID (hwp): spsmo
                Title: SAGE Open Medicine
                Publisher: SAGE Publications (Sage UK: London, England )
                ISSN (Electronic): 2050-3121
                Publication date (Electronic): 10 September 2020
                Publication date Collection: 2020
                Volume: 8
                Electronic Location Identifier: 2050312120957925
                Affiliations
                [1 ]Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
                [2 ]Department of Zoology and Environment Sciences, Faculty of Science, University of Colombo, Colombo, Sri Lanka
                [3 ]Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka
                Author notes
                [*]Suranjith L Seneviratne, Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Email: suran200@ 123456yahoo.co.uk
                Author information
                https://orcid.org/0000-0002-6548-5673
                Article
                Publisher ID: 10.1177_2050312120957925
                DOI: 10.1177/2050312120957925
                PMC ID: 7491214
                PubMed ID: 36451533
                SO-VID: 416164a2-eb9e-494f-b379-7345cb3525c5
                Copyright © © The Author(s) 2020
                License:

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                Date received : 5 June 2020
                Date accepted : 20 August 2020
                Categories
                Subject: Review Paper
                Custom metadata
                cover-date January-December 2020
                typesetter ts1

                Keywords: covid-19,sars-cov-2,neurological manifestations,cerebrovascular disease,taste and smell impairments,guillain-barré syndrome
                Data availability:
                Keywords: covid-19, sars-cov-2, neurological manifestations, cerebrovascular disease, taste and smell impairments, guillain-barré syndrome

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content931

                See all similar

                Cited by18

                See all cited by

                Most referenced authors2,006

                See all reference authors