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      CD1d Modulates Colonic Inflammation in NOD2-/- Mice by Altering the Intestinal Microbial Composition Comprising Acetatifactor muris.

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          Abstract

          NOD2 and CD1d play a key role in innate immunity by recognizing conserved molecular patterns of pathogens. While NOD2-/- and CD1d-/- mice display structural and functional alterations in Paneth cells, animal studies have reported no impact of NOD2 or CD1d deficiency on experimental colitis. NOD2 mutations increase the susceptibility to inflammatory bowel diseases and the CD1d bound to α-galactosylceramide [α-GalCer] alleviates intestinal inflammation. We evaluated the effect of CD1d modulation on experimental colitis in NOD2-/- mice.

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          Author and article information

          Journal
          J Crohns Colitis
          Journal of Crohn's & colitis
          Oxford University Press (OUP)
          1876-4479
          1873-9946
          Aug 14 2019
          : 13
          : 8
          Affiliations
          [1 ] Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea.
          [2 ] Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
          Article
          5490126
          10.1093/ecco-jcc/jjz025
          31094420
          3f8f067a-3f4c-4e4f-9495-1cac160f7d74
          Copyright © 2019 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
          History

          Acetatifactor muris ,intestinal microbiota,Paneth cells,NOD2,CD1d

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