CD1d Modulates Colonic Inflammation in NOD2-/- Mice by Altering the Intestinal Microbial Composition Comprising Acetatifactor muris.

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Abstract

NOD2 and CD1d play a key role in innate immunity by recognizing conserved molecular patterns of pathogens. While NOD2-/- and CD1d-/- mice display structural and functional alterations in Paneth cells, animal studies have reported no impact of NOD2 or CD1d deficiency on experimental colitis. NOD2 mutations increase the susceptibility to inflammatory bowel diseases and the CD1d bound to α-galactosylceramide [α-GalCer] alleviates intestinal inflammation. We evaluated the effect of CD1d modulation on experimental colitis in NOD2-/- mice.

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Author and article information

Journal

Journal ID (iso-abbrev): J Crohns Colitis

Title: Journal of Crohn's & colitis

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1876-4479

ISSN (Print): 1873-9946

Publication date (Electronic): Aug 14 2019

Volume: 13

Issue: 8

Affiliations

[1 ] Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea.

[2 ] Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Article

Publisher Item ID: 5490126

DOI: 10.1093/ecco-jcc/jjz025

PubMed ID: 31094420

SO-VID: 3f8f067a-3f4c-4e4f-9495-1cac160f7d74

History

Keywords: Acetatifactor muris ,intestinal microbiota,Paneth cells,NOD2,CD1d

Data availability:

Keywords: Acetatifactor muris , intestinal microbiota, Paneth cells, NOD2, CD1d

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