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Physiology and role of irisin in glucose homeostasis
Nikolaos Perakakis ,
Georgios A. Triantafyllou ,
José Manuel Fernández-Real ,
Joo Young Huh ,
Kyung Hee Park ,
Jochen Seufert ,
Christos S. Mantzoros
February 17 2017
February 17 2017
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Abstract
Despite great interest in the role of irisin in glucose homeostasis, controversy still exists regarding the function, and even the existence, of this myokine. Here, Perakakis and colleagues provide an extensive evaluation of the evidence for the physiology and function of irisin from both animal and human studies.