Cefiderocol for the Treatment of Adult and Pediatric Patients With Cystic Fibrosis and <i>Achromobacter xylosoxidans</i> Infections

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Abstract

Treatment options for Achromobacter xylosoxidans are limited. Eight cystic fibrosis patients with A. xylosoxidans were treated with 12 cefiderocol courses. Pretreatment in vitro resistance was seen in 3 of 8 cases. Clinical response occurred after 11 of 12 treatment courses. However, microbiologic relapse was observed after 11 of 12 treatment courses, notably without emergence of resistance.

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Most cited references 14

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Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial

Matteo Bassetti, Roger Echols, Yuko Matsunaga … (2020)

New antibiotics are needed for the treatment of patients with life-threatening carbapenem-resistant Gram-negative infections. We assessed the efficacy and safety of cefiderocol versus best available therapy in adults with serious carbapenem-resistant Gram-negative infections.

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Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial

Richard G Wunderink, Yuko Matsunaga, Mari Ariyasu … (2020)

Nosocomial pneumonia due to multidrug-resistant Gram-negative pathogens poses an increasing challenge. We compared the efficacy and safety of cefiderocol versus high-dose, extended-infusion meropenem for adults with nosocomial pneumonia.

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Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial

Simon Portsmouth, David van Veenhuyzen, Roger Echols … (2018)

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Author and article information

Journal

Title: Clinical Infectious Diseases

Publisher: Oxford University Press (OUP)

ISSN (Print): 1058-4838

ISSN (Electronic): 1537-6591

Publication date Created: October 01 2021

Publication date Created: October 05 2021

Publication date Created: December 12 2020

Publication date Other: October 01 2021

Publication date (Print): October 05 2021

Publication date (Electronic): December 12 2020

Volume: 73

Issue: 7

Pages: e1754-e1757

Affiliations

[1 ]Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA

[2 ]Clinical Microbiology Laboratory, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA

[3 ]Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

[4 ]Department of Pharmacy, Advent Health Orlando, Orlando, Florida, USA

[5 ]Department of Microbiology/Virology/Immunology, Advent Health, Orlando, Florida, USA

[6 ]Prisma Health Children’s Hospital–Midlands, Columbia, South Carolina, USA

[7 ]Department of Pediatrics, University of South Carolina School of Medicine, Columbia, South Carolina, USA

[8 ]Adaptive Phage Therapeutics, Gaithersburg, Maryland, USA

[9 ]Division of Infectious Diseases, University of Connecticut, Farmington, Connecticut, USA

[10 ]Department of Pharmacy, Hartford Hospital, Hartford, Connecticut, USA

[11 ]Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

[12 ]Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

[13 ]Division of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Article

DOI: 10.1093/cid/ciaa1847

PubMed ID: 33313656

SO-VID: 3e24fe64-da01-4fda-83ad-79b039dccf24

License:

https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

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