Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial.

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Abstract

Calcitonin gene-related peptide (CGRP) is crucial in the pathophysiology of migraine. We assessed the safety, tolerability, and efficacy of ALD403, a genetically engineered humanised anti-CGRP antibody, for migraine prevention.

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Journal

Journal ID (iso-abbrev): Lancet Neurol

Title: The Lancet. Neurology

ISSN (Electronic): 1474-4465

ISSN (Print): 1474-4422

Publication date (Electronic): Nov 2014

Volume: 13

Issue: 11

Affiliations

[1 ] Department of Neurology, Mayo Clinic, Phoenix, AZ, USA. Electronic address: dodick.david@mayo.edu.

[2 ] NIHR-Wellcome Trust Clinical Research Facility, King's College London, London, UK; Department of Neurology, University of California, San Francisco, CA, USA.

[3 ] Department of Neurology, Thomas Jefferson University, Jefferson Headache Center, Philadelphia, PA, USA.

[4 ] Department of Neurology and the Montefiore Headache Center, Albert Einstein College of Medicine, Bronx, NY, USA.

[5 ] Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

[6 ] MD Clinical, Hallandale Beach, FL, USA.

[7 ] California Medical Clinic for Headache, Santa Monica, CA, USA.

[8 ] Women's Clinical Research Center, Seattle, WA, USA.

[9 ] Miami Research Associates, South Miami, FL, USA.

[10 ] Boston Clinical Trials, Boston, MA, USA.

[11 ] Pacific Northwest Statistical Consulting, Woodinville, WA, USA.

[12 ] Alder BioPharmaceuticals, Bothell, WA, USA.

Article

Publisher Item ID: S1474-4422(14)70209-1

DOI: 10.1016/S1474-4422(14)70209-1

PubMed ID: 25297013

SO-VID: 3d345146-0077-4865-a2f7-cbcc9285c2fa

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