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      A Controlled Trial of Erenumab for Episodic Migraine

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          Abstract

          <p class="first" id="d1992599e125">We tested erenumab, a fully human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor, for the prevention of episodic migraine. </p>

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          Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial.

          Stewart Tepper, Messoud Ashina, Uwe Reuter … (2017)
          The calcitonin gene-related peptide (CGRP) pathway is important in migraine pathophysiology. We assessed the efficacy and safety of erenumab, a fully human monoclonal antibody against the CGRP receptor, in patients with chronic migraine.
          Article 0 comments Cited 316 times – based on 0 reviews     Review now
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            Migraine--current understanding and treatment.

            Peter J Goadsby, Richard B Lipton, Michel D Ferrari (2002)
            Article 0 comments Cited 278 times – based on 0 reviews     Review now
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              CGRP may play a causative role in migraine.

              Annette Jacobsen, Jes Olesen, Lene Iversen … (2002)
              Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in external jugular venous blood during migraine attacks. However, it is unknown whether this is secondary to migraine or whether CGRP may cause headache. In a double-blind crossover study, the effect of human alphaCGRP (2 microg/min) or placebo infused intravenously for 20 min was studied in 12 patients suffering from migraine without aura. Headache intensity was scored on a scale from 0 to 10. Two patients were excluded due to severe hypotension and one because she had an infection. In the first hour median peak headache score was 1.0 in the halphaCGRP group vs. 0 in the placebo group (P < 0.01). During the following 11 h all patients experienced headaches after halphaCGRP vs. one patient after placebo (P = 0.0004). The median maximal headache score was 4 after CGRP and 0 after placebo (P = 0.006). In three patients after halphaCGRP, but in no patients after placebo, the delayed headache fulfilled the IHS criteria for migraine without aura. As intravenous administration of halphaCGRP causes headache and migraine in migraineurs, our study suggests that the increase in CGRP observed during spontaneous migraine attacks may play a causative role.
              Article 0 comments Cited 196 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: New England Journal of Medicine
                Abbreviated Title: N Engl J Med
                Publisher: New England Journal of Medicine (NEJM/MMS)
                ISSN (Print): 0028-4793
                ISSN (Electronic): 1533-4406
                Publication date Created: November 30 2017
                Publication date (Print): November 30 2017
                Volume: 377
                Issue: 22
                Pages: 2123-2132
                Article
                DOI: 10.1056/NEJMoa1705848
                PubMed ID: 29171821
                SO-VID: 5478f0b4-b800-4a46-ac3b-45ac9b5e6407
                Copyright © © 2017
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