CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis.

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Abstract

Alzheimer's disease biomarkers are important for early diagnosis in routine clinical practice and research. Three core CSF biomarkers for the diagnosis of Alzheimer's disease (Aβ42, T-tau, and P-tau) have been assessed in numerous studies, and several other Alzheimer's disease markers are emerging in the literature. However, there have been no comprehensive meta-analyses of their diagnostic performance. We systematically reviewed the literature for 15 biomarkers in both CSF and blood to assess which of these were most altered in Alzheimer's disease.

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Journal

Journal ID (iso-abbrev): Lancet Neurol

Title: The Lancet. Neurology

ISSN (Electronic): 1474-4465

ISSN (Print): 1474-4422

Publication date (Electronic): Jun 2016

Volume: 15

Issue: 7

Affiliations

[1 ] Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. Electronic address: bob.olsson@neuro.gu.se.

[2 ] Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

[3 ] Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Biomedical Sciences, University of Antwerp, Belgium.

[4 ] Department of Radiation Physics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

[5 ] Alzforum, Cambridge, MA, USA.

[6 ] Unit for Health Metrics, Department of Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

[7 ] Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.

Article

Publisher Item ID: S1474-4422(16)00070-3

DOI: 10.1016/S1474-4422(16)00070-3

PubMed ID: 27068280

SO-VID: 3bd15601-7d2c-405e-baaa-6581a6a37c37

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