Immunocytochemical p63 expression discriminates between primary cutaneous follicle centre cell and diffuse large B cell lymphoma-leg type, and is of the TAp63 isoform.

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Abstract

The p63 gene shares structural and functional homologies with the p53 family of transcriptional activators, but differs in exhibiting a consistent expression pattern in normal tissues. Although p63 is rarely mutated in malignancy studies of primary human tumours and cell lines suggest that p63 may promote tumour development. In non-Hodgkin's nodal lymphoma, TAp63 expression in follicular lymphoma (54%) and diffuse large B cell lymphoma (34%) has been described and correlated with the proliferative index. In this study, we analysed a series of primary cutaneous B cell lymphomas for immunohistochemical expression of p63.

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Journal

Journal ID (iso-abbrev): Histopathology

Title: Histopathology

ISSN (Electronic): 1365-2559

ISSN (Print): 0309-0167

Publication date (Electronic): Jul 2016

Volume: 69

Issue: 1

Affiliations

[1 ] St John's Institute of Dermatology, London, UK.

[2 ] Department of Dermatology, Stanford University, Stanford, CA, USA.

[3 ] Division of Health and Social Care Research, Kings College London, London, UK.

[4 ] Department of Pathology, UCSF, San Francisco, CA, USA.

[5 ] Department of Dermatology, Boston University Medical Center, Boston, MA, USA.

[6 ] Department of Pathology, Stanford University, Stanford, CA, USA.

[7 ] Dermatopathology Department, Yale University School of Medicine, New Haven, CT, USA.

[8 ] Lake Diagnostics Florida, Lake City, FL, USA.

[9 ] Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

[10 ] Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.

[11 ] Dundee Cancer Centre, Ninewells Hospital and Medical School, Dundee, UK.

Article

DOI: 10.1111/his.12855

PubMed ID: 26332336

SO-VID: 3b2de0d4-f45e-4e8d-b3e1-1cadc2e9176d

History

Keywords: B cell lymphoma,cutaneous,immunohistochemistry,oncogene,p63

Data availability:

Keywords: B cell lymphoma, cutaneous, immunohistochemistry, oncogene, p63

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