Filamins as integrators of cell mechanics and signalling.

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Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

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Journal

Journal ID (iso-abbrev): Nat Rev Mol Cell Biol

Title: Nature reviews. Molecular cell biology

Publisher: Springer Science and Business Media LLC

ISSN: 1471-0072

ISSN (Print): 1471-0072

Publication date (Electronic): Feb 2001

Volume: 2

Issue: 2

Affiliations

[1 ] Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. tstossel@rics.bwh.harvard.edu

Article

DOI: 10.1038/35052082

PubMed ID: 11252955

SO-VID: 37e2a6af-9ac2-4c77-84a1-85f37b28a414

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