Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster.

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Abstract

The ability of cells to survive and recover from deteriorating effects of endoplasmic reticulum (ER) stress relies on the unfolded protein response (UPR). The signaling pathway of Ire1p mediate mRNA splicing plays diverge role in UPR response in different organisms from yeast to mammals. Here, we report that Ire1p mediated XBP1 mRNA splicing mechanism is extremely conserved and exerts a critical role for modulating Xbp1 protein synthesis in Drosophila melanogaster. This system is operative in Drosophila S2 cells as a prominent mechanism to mediate transcriptional activation of UPR responsive genes during ER stress.

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Journal

Journal ID (iso-abbrev): Biochem Biophys Res Commun

Title: Biochemical and biophysical research communications

Publisher: Elsevier BV

ISSN: 0006-291X

ISSN (Print): 0006-291X

Publication date (Electronic): Mar 16 2007

Volume: 354

Issue: 3

Affiliations

[1 ] The Institute of Molecular Biology and Genetics, Mahidol University, Salaya, Nakhonpathom 73170, Thailand.

Article

Publisher Item ID: S0006-291X(07)00102-7

DOI: 10.1016/j.bbrc.2007.01.056

PubMed ID: 17266933

SO-VID: 372b092c-a97a-4914-b8bb-cbb0e54a0d4e

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