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      Mainstreamed genetic testing of breast cancer patients: experience from a single surgeon’s practice in a large US Academic Center

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          Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation.

          Olaparib is an oral poly(adenosine diphosphate-ribose) polymerase inhibitor that has promising antitumor activity in patients with metastatic breast cancer and a germline BRCA mutation.
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            Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer

            Poly(adenosine diphosphate-ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality. New therapies are needed to reduce recurrence in patients with BRCA1 or BRCA2 germline mutation-associated early breast cancer.
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              Is Open Access

              SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence): revised publication guidelines from a detailed consensus process

              Since the publication of Standards for QUality Improvement Reporting Excellence (SQUIRE 1.0) guidelines in 2008, the science of the field has advanced considerably. In this manuscript, we describe the development of SQUIRE 2.0 and its key components. We undertook the revision between 2012 and 2015 using (1) semistructured interviews and focus groups to evaluate SQUIRE 1.0 plus feedback from an international steering group, (2) two face-to-face consensus meetings to develop interim drafts and (3) pilot testing with authors and a public comment period. SQUIRE 2.0 emphasises the reporting of three key components of systematic efforts to improve the quality, value and safety of healthcare: the use of formal and informal theory in planning, implementing and evaluating improvement work; the context in which the work is done and the study of the intervention(s). SQUIRE 2.0 is intended for reporting the range of methods used to improve healthcare, recognising that they can be complex and multidimensional. It provides common ground to share these discoveries in the scholarly literature (http://www.squire-statement.org).
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                Author and article information

                Journal
                Familial Cancer
                Familial Cancer
                Springer Science and Business Media LLC
                1389-9600
                1573-7292
                October 2023
                June 24 2023
                October 2023
                : 22
                : 4
                : 467-474
                Article
                10.1007/s10689-023-00342-3
                37354306
                3712c506-77bb-4011-9672-19626f964932
                © 2023

                https://www.springernature.com/gp/researchers/text-and-data-mining

                https://www.springernature.com/gp/researchers/text-and-data-mining

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