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      Comparison of mammography and ultrasonography findings with pathology results in patients with breast cancer in Birjand, Iran

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          Abstract

          Background

          Early diagnosis of breast cancer, the incidence of which among Iranian women is about a decade earlier than in developed countries, is important.

          Objective

          To compare mammography and ultrasonography findings with those of pathology in patients with breast cancer.

          Methods

          This descriptive cross-sectional study was performed using medical records of 79 patients with breast malignancies, who were referred to Imam Reza Hospital and private laboratories of Birjand, Iran, from December 2012 to December 2014. The patients’ information was recorded using a checklist, which included name, code, age, ultrasonography, and mammography results and pathology reports. The results of ultrasonography and mammography were compared with pathology findings as the gold standard. SPSS Version 21 was used for data analysis.

          Results

          The mean age of the patients was 46.94 ± 11.76 years. The results showed that 74.7%, 16.5%, and 7.6% of the patients had ductal carcinoma, lobular carcinoma, and mixed carcinoma, respectively. About 72.5%, 24.6%, and 2.9% of the patients had stage 2, 3, and 1 breast cancer, respectively. In addition, both breasts were involved in 1.3% of the patients. The ultrasound findings were positive and false negative in 97.5% and 2.5% of the cases. Moreover, the mammography results were positive and false negative in 98.7% and 1.3% of the patients.

          Conclusion

          This study showed that mammography is the preferred modality in screening breast cancer patients; the use of complementary tests such as ultrasonography is recommended, especially in high-risk women.

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          Most cited references16

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          Epidemiology and prognosis of breast cancer in young women.

          Breast cancer is the most common malignancy in women with 6.6% of cases diagnosed in young women below the age of 40. Despite variances in risk factors, Age Standardized Incidence Rates of breast cancer in young women vary little between different countries. Review of modifiable risk factors shows that long-term use of oral contraceptives, low body mass index (BMI) and high animal fat diet consumption are associated with increased risk of premenopausal breast cancer. Decreased physical activity and obesity increase risks of breast cancer in postmenopausal women, but data on premenopausal women rather shows that high BMI is associated with decreased risk of breast cancer. Non-modifiable risk factors such as family history and genetic mutations do account for increased risks of breast cancer in premenopausal women. Breast cancer in young women is associated with adverse pathological factors, including high grade tumors, hormone receptor negativity, and HER2 overexpression. This has a significant negative impact on the rate of local recurrence and overall survival. Moreover, younger women often tend to present with breast cancer at a later stage than their older counterparts, which further explains worse outcome. Despite these factors, age per se is still being advocated as an independent role player in the prognosis. This entails more aggressive treatment modalities and the need for closer monitoring and follow-up.
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            Cancer occurrence in Iran in 2002, an international perspective.

            For almost 30 years no population-based cancer statistics have been available with which to estimate the cancer burden in Iran. In 2002 and 2003 two separate reports of population based cancer registries were published from Iran and the cancer incidence rates from these sources have permitted informed estimates of cancer incidence and mortality to be prepared. They suggest that more than 51,000 cases of cancer are diagnosed and 35,000 deaths due to cancer occur each year. The 5 most common cancers in males (by ASR) are stomach (26.1 per 10(5)), esophagus (17.6 ), colon-rectum (8.3), bladder (8.0) and leukemia (4.8), and in females are breast (17.1), esophagus (14.4), stomach (11.1), colon-rectum (6.5) and cervix uteri (4.5). The incidence rates of esophageal and stomach cancer in Iran are high, well above the world average, while the incidence of lung cancer is very low. Breast cancer, although the most common cancer of females in Iran, has rates that are low by world standards, especially those observed in Europe and USA. Similarly, the incidence of cervix cancer in Iran is very low, even lower than such low risk countries as China, Kuwait and Spain. Comparing these rates with the data of 30 years ago, the incidence of esophageal cancer has decreased dramatically, but gastric cancer has increased about two fold.
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              Breast cancer in Iran: results of a multi-center study.

              Breast Cancer is the most common cancer in Iranian women. This study aims to demonstrate the characteristics of breast diseases- and especially breast cancer- according to pathologic records in Tehran, Iran. In this cross-sectional study, all records of pathologic specimens (biopsy or mastectomy) categorized as "breast diseases" from 1996 to 2000 in five teaching hospitals in Tehran were studied. For each patient, sex, age, breast pathology, pathological staging of malignant lesions, side and location of the tumor and the type of surgery were reviewed by a trained general practitioner. SPSS version 10 was used for statistical analysis. The mean age of women with breast cancer was 48.8. The highest frequency of malignancies was observed in the 40-49 age group (31.8%). Twenty-three percent of breast cancers were observed in women younger than 40 years. About 83 percent of malignant lesions in women were in T2, T3 or T4 at diagnosis. Only about 4 percent of women with breast cancers had tumors in stage I or in-situ carcinomas. Nearly 70 percent of the cancers were detected only after lymph node involvement. Only 4.3 percent of our female cases had the chance of conservative mastectomy. Twenty-eight percent of specimens from biopsies in women were malignant. In Iran, breast cancer affects women at least one decade younger than their counterparts in developed countries. A considerable proportion of our cases (96%) were in stage II or III at diagnosis. These results show advanced cases at presentation in Iran which further mandate a national cancer detection program involving more effective public education and encouragement of women for breast self-examination and participation in screening campaigns.
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                Author and article information

                Journal
                Electron Physician
                Electron Physician
                Electronic physician
                Electronic Physician
                Electronic physician
                2008-5842
                October 2017
                25 October 2017
                : 9
                : 10
                : 5494-5498
                Affiliations
                [1 ]Associate Professor of Pathology, Department of Pathology, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, Iran
                [2 ]Assistant Professor of Surgery, Department of Surgery, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, Iran
                [3 ]Associate Professor of Radiology, Department of Radiology, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, Iran
                [4 ]Naeeme Abdollahi, Intern, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, Iran
                Author notes
                Corresponding author: Associate Professor Dr. Mahyar Mohammadifard, Department of Radiology, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, Iran. Tel/Fax: +985138414499, Email: Mahyarmohammadifard@ 123456yahoo.com
                Article
                epj-09-5494
                10.19082/5494
                5718853
                29238489
                367a3f5e-4cc0-426b-a1d7-2e8115f2a1e1
                © 2017 The Authors

                This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

                History
                : 14 June 2016
                : 02 November 2016
                Categories
                Original Article

                biopsy,breast cancer,mammography,ultrasonography
                biopsy, breast cancer, mammography, ultrasonography

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