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      • Record: found
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      Is Open Access

      MAPLE Fabricated Fe 3O 4@ Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes

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          Abstract

          Cinnamomum verum-functionalized Fe 3O 4 nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe 3O 4@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization.

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          Quorum sensing in biofilms--how to destroy the bacterial citadels or their cohesion/power?

          Veronica Lazǎr (2011)
          Biofilms or microbial communities formed by adherent and cohesive cells on cellular or inert substrata (like medical devices), are involved in ≈ 60% of all infections and characterized by moderate intensity symptoms, chronic evolution and resistance to antibiotics. Biofilms' pathogenicity, even of those formed by opportunistic microorganisms, is amplified by two major biofilm characteristics: 1) the increased resistance to antimicrobials; 2) the protection of cells against the host's defence mechanisms. The studies at the molecular level shown that the biofilms formation is controlled by cell-to-cell signalling mechanisms and the gene regulation during biofilm growth is due to the accumulation of signal molecules. In this regard, quorum sensing mechanism (QS) is defined as a cell-density dependent bacterial intercellular communication, involved in gene expression (e.g. virulence genes for exoenzymes, exopolysaccharides) and the consequent changed behaviour of biofilm's cells, including the resistance to stress conditions; this resistance is different of well known antibioresistance, being named phenotypical resistance or tolerance. Considering the differences in physiology and susceptibility to antibiotics of biofilm embedded bacteria, as well as their increased power against the host defence responses, there are necessary new strategies for prevention and therapy of biofilm associated infections. The dental plaque is a typical example of biofilm, involved in the ethiology of cariogenesis and periodontal diseases associated with local chronic inflammation and cytokines production. The genetical and phenotypical versatility of the biofilm's cells represent a challenge for discovering new methods of treatment and prevention of biofilm associated infections. A novel class of antibiofilm and antipathogenic therapeutics which are interfering with a new target - the QS pathway, not based on growth inhibition and called QS inhibitors, natural, with different origins or artificial, are now developing as an alternative to antibiotherapy. Copyright © 2011. Published by Elsevier Ltd.
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            Complications after percutaneous endoscopic gastrostomy in a prospective study.

            Jesper Lagergren, Lena Martin, Fredrik Mattsson … (2012)
            Insertion of a percutaneous endoscopic gastrostomy (PEG) is an increasingly common procedure in patients with nutritional needs and dysphagia. Better knowledge of rates and patterns of complications after PEG might influence decision-making. The objective was to prospectively evaluate the rate of six pre-defined complications (leakage, diarrhea, constipation, abdominal pain, fever and peristomal infection) and mortality occurring within 2 months after PEG in an unselected sample of patients. All patients (n = 484) who had a PEG inserted at the hospital during the study period were included. Kaplan-Meier curves were used to estimate mortality over the first 60 days following PEG and Fisher's exact test was used to test equality of proportions. Of the 484 patients included, 85 (18%) died within 2 months after PEG insertion. The risk of early mortality was higher in the group with neurological disease than in the group with a tumor as indication (p < 0.001). After excluding mortality, the overall complication rates at 2 weeks and 2 months were 39% and 27%, respectively. The most common complications within 2 weeks were abdominal pain (13%), peristomal infection (11%), diarrhea (11%) and leakage (10%). At 2 months the most frequent complications were diarrhea (10%), leakage (8%) and peristomal infection (6%). In the short-term perspective, there is a substantial risk of complications, including mortality, after PEG insertion. This should be considered during clinical decision-making and when informing the patients and caregivers.
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              Application of second derivative spectroscopy for increasing molecular specificity of Fourier transform infrared spectroscopic imaging of articular cartilage.

              L. Rieppo, S. Saarakkala, T Närhi … (2012)
              Fourier transform infrared (FT-IR) spectroscopic imaging is a promising method that enables the analysis of spatial distribution of biochemical components within histological sections. However, analysis of FT-IR spectroscopic data is complicated since absorption peaks often overlap with each other. Second derivative spectroscopy is a technique which enhances the separation of overlapping peaks. The objective of this study was to evaluate the specificity of the second derivative peaks for the main tissue components of articular cartilage (AC), i.e., collagen and proteoglycans (PGs).
              Article 0 comments Cited 46 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 27 June 2014
                Publication date Collection: July 2014
                Volume: 19
                Issue: 7
                Pages: 8981-8994
                Affiliations
                [1 ]ENT, “Carol Davila” University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania; E-Mails: dr_alina.anghel@ 123456yahoo.com (A.G.A.); ionangheldoc@ 123456yahoo.com (I.A.)
                [2 ]Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest 30932, Romania
                [3 ]Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania; E-Mails: grumezescu@ 123456yahoo.com (A.M.G.); valentina_grumezescu@ 123456yahoo.com (V.G.); elena_oprea_93@ 123456yahoo.co.uk (A.E.O.); alina_m_h@ 123456yahoo.com (A.M.H.)
                [4 ]AMG Transcend, Polizu Street no 1-7, Bucharest 011061, Romania
                [5 ]Departamento de Química Fisica, Universidade de Vigo, 36310 Vigo, Pontevedra, Spain
                [6 ]National Institute for Lasers, Plasma & Radiation Physics, Lasers Department, P.O. Box MG-36, Bucharest-Magurele, Bucharest 769231, Romania; E-Mail: gabriel.socol@ 123456inflpr.ro
                [7 ]Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology “Nicolae Simionescu” (ICBP), Bucharest 050568, Romania; E-Mail: floriniordache84@ 123456yahoo.com
                [8 ]Microbiology Immunology Department, Faculty of Biology, University of Bucharest, AleeaPortocalelor no 1-3, Bucharest 060101, Romania
                Author notes
                [* ]Author to whom correspondence should be addressed; E-Mail: mariana.chirea@ 123456uvigo.es or mariana.chirea@ 123456fc.up.pt ; Tel.: +34-986-81-86-17; Fax: +34-986-81-25-56.
                Article
                Publisher ID: molecules-19-08981
                DOI: 10.3390/molecules19078981
                PMC ID: 6271288
                PubMed ID: 24979402
                SO-VID: 36609eff-9f6a-4be0-80b2-fee6d80f6f9b
                Copyright © © 2014 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 20 May 2014
                Date revision received : 14 June 2014
                Date accepted : 23 June 2014
                Categories
                Subject: Article

                Keywords: magnetite nanoparticles,drug delivery,maple,laser processing,essential oils,natural products
                Data availability:
                Keywords: magnetite nanoparticles, drug delivery, maple, laser processing, essential oils, natural products

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