For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
19
views
88
references
 Top references
cited by
31
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      421
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Current concepts for the evaluation and management of diabetic foot ulcers

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          • The lifetime risk for diabetic patients to develop a diabetic foot ulcer (DFU) is 25%. In these patients, the risk of amputation is increased and the outcome deteriorates.

          • More than 50% of non-traumatic lower-extremity amputations are related to DFU infections and 85% of all lower-extremity amputations in patients with diabetes are preceded by an ulcer; up to 70% of diabetic patients with a DFU-related amputation die within five years of their amputation.

          • Optimal management of patients with DFUs must include clinical awareness, adequate blood glucose control, periodic foot inspection, custom therapeutic footwear, off-loading in high-risk patients, local wound care, diagnosis and control of osteomyelitis and ischaemia.

          Cite this article: EFORT Open Rev 2018;3:513-525. DOI: 10.1302/2058-5241.3.180010

          Related collections

          Most cited references88

          • Record: found
          • Abstract: found
          • Article: not found

          Clinical application of growth factors and cytokines in wound healing.

          Stephan Barrientos, Harold Brem, Olivera Stojadinovic … (2014)
          Wound healing is a complex and dynamic biological process that involves the coordinated efforts of multiple cell types and is executed and regulated by numerous growth factors and cytokines. There has been a drive in the past two decades to study the therapeutic effects of various growth factors in the clinical management of nonhealing wounds (e.g., pressure ulcers, chronic venous ulcers, diabetic foot ulcers). For this review, we conducted an online search of Medline/PubMed and critically analyzed the literature regarding the role of growth factors and cytokines in the management of these wounds. We focused on currently approved therapies, emerging therapies, and future research possibilities. In this review, we discuss four growth factors and cytokines currently being used on and off label for the healing of wounds. These include granulocyte-macrophage colony-stimulating factor, platelet-derived growth factor, vascular endothelial growth factor, and basic fibroblast growth factor. While the clinical results of using growth factors and cytokines are encouraging, many studies involved a small sample size and are disparate in measured endpoints. Therefore, further research is required to provide definitive evidence of efficacy. © 2014 by the Wound Healing Society.
          Article 0 comments Cited 183 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes.

            Benjamin A Lipsky, Javier Aragón-Sánchez, Mathew A. Diggle … (2016)
            Article 0 comments Cited 160 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine.

              Anil Hingorani, Glenn M LaMuraglia, Rolf-Peter Henke … (2016)
              Diabetes mellitus continues to grow in global prevalence and to consume an increasing amount of health care resources. One of the key areas of morbidity associated with diabetes is the diabetic foot. To improve the care of patients with diabetic foot and to provide an evidence-based multidisciplinary management approach, the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine developed this clinical practice guideline.
              Article 0 comments Cited 154 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): EFORT Open Rev
                Journal ID (iso-abbrev): EFORT Open Rev
                Title: EFORT Open Reviews
                Publisher: British Editorial Society of Bone and Joint Surgery
                ISSN (Electronic): 2058-5241
                Publication date Collection: September 2018
                Publication date (Electronic): 27 September 2018
                Volume: 3
                Issue: 9
                Pages: 513-525
                Affiliations
                [1 ]First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece
                [2 ]Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece
                Author notes
                [*]A. F. Mavrogenis, First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, 41 Ventouri Street, 15562 Holargos, Athens, Greece. Email: afm@ 123456otenet.gr
                Article
                Publisher ID: 10.1302_2058-5241.3.180010
                DOI: 10.1302/2058-5241.3.180010
                PMC ID: 6174858
                SO-VID: 362c745a-fa43-453d-b02e-9a583f6ef0a3
                Copyright © © 2018 The author(s)
                License:

                This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.

                History
                Categories
                Subject: Foot & Ankle
                Subject: 3
                Subject: Diabetic Foot Ulcers
                Subject: Infection
                Subject: Osteomyelitis
                Subject: Revascularization
                Subject: Wound Dressings

                Keywords: diabetic foot ulcers,infection,osteomyelitis,revascularization,wound dressings
                Data availability:
                Keywords: diabetic foot ulcers, infection, osteomyelitis, revascularization, wound dressings

                Comments

                Comment on this article

                scite_

                Similar content421

                See all similar

                Cited by31

                See all cited by

                Most referenced authors1,262

                See all reference authors