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Abstract
Introduction:
South African men are less likely to get tested for HIV than women and are more likely
to commence antiretroviral treatment (ART) at later stages of disease, default on
treatment, and to die from AIDS compared with women. The purpose of this study was
to conduct formative research into the ideational and behavioral factors that enable
or create obstacles to mens' uptake of HIV counseling and testing (HCT) and ART. The
study consulted men with a goal of developing a communication campaign aimed at improving
the uptake of HIV testing and ART initiation among men.
Methods:
Eleven focus groups and 9 in-depth interviews were conducted with 97 male participants
in 6 priority districts in 4 South African provinces in rural, peri-urban, and urban
localities.
Results:
Fears of compromised masculine pride and reputation, potential community rejection,
and fear of loss of emotional control (“the stress of knowing”) dominated men's rationales
for avoiding HIV testing and treatment initiation.
Conclusions:
A communication campaign was developed based on the findings. Creative treatments
aimed at redefining a ‘strong’ man as someone who faces his fears and knows his HIV
status. The resultant campaign concept was: “positive or negative—you are still the
same person.”
Prognostic models have been developed for patients infected with HIV-1 who start combination antiretroviral therapy (ART) in high-income countries, but not for patients in sub-Saharan Africa. We developed two prognostic models to estimate the probability of death in patients starting ART in sub-Saharan Africa. We analysed data for adult patients who started ART in four scale-up programmes in Côte d'Ivoire, South Africa, and Malawi from 2004 to 2007. Patients lost to follow-up in the first year were excluded. We used Weibull survival models to construct two prognostic models: one with CD4 cell count, clinical stage, bodyweight, age, and sex (CD4 count model); and one that replaced CD4 cell count with total lymphocyte count and severity of anaemia (total lymphocyte and haemoglobin model), because CD4 cell count is not routinely measured in many African ART programmes. Death from all causes in the first year of ART was the primary outcome. 912 (8.2%) of 11 153 patients died in the first year of ART. 822 patients were lost to follow-up and not included in the main analysis; 10 331 patients were analysed. Mortality was strongly associated with high baseline CD4 cell count (>/=200 cells per muL vs /=60 kg vs <45 kg; 0.23, 0.18-0.30), and anaemia status (none vs severe: 0.27, 0.20-0.36). Other independent risk factors for mortality were low total lymphocyte count, advanced age, and male sex. Probability of death at 1 year ranged from 0.9% (95% CI 0.6-1.4) to 52.5% (43.8-61.7) with the CD4 model, and from 0.9% (0.5-1.4) to 59.6% (48.2-71.4) with the total lymphocyte and haemoglobin model. Both models accurately predict early mortality in patients starting ART in sub-Saharan Africa compared with observed data. Prognostic models should be used to counsel patients, plan health services, and predict outcomes for patients with HIV-1 infection in sub-Saharan Africa. US National Institute of Allergy And Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and National Cancer Institute. Copyright 2010 Elsevier Ltd. All rights reserved.
Uptake of HIV testing and antiretroviral therapy (ART) services during antenatal care (ANC) in rural Mozambique is disappointing. To nurture supportive male engagement in ANC services, we partnered with traditional birth attendants and trained a new type of male-to-male community health agent, "Male Champions", who focused on counseling male partners to create new, male-friendly community norms around engagement in spousal/partner pregnancies. We assessed ANC service uptake using a pre-post intervention design. The intervention was associated with increases in: (1) uptake of provider-initiated counseling and testing among pregnant woman (81 vs. 92 %; p < 0.001); (2) male engagement in ANC (5 vs. 34 %; p < 0.001); and (3) uptake of ART (8 vs. 19 %; p < 0.001). When men accepted HIV testing, rates of testing rose markedly among pregnant women. With the challenges in scale-up of Option B+ in sub-Saharan Africa, similar interventions may increase testing and treatment acceptability during pregnancy.
Journal ID (iso-abbrev): J. Acquir. Immune Defic. Syndr
Journal ID (publisher-id): qai
Title:
Journal of Acquired Immune Deficiency Syndromes (1999)
Publisher:
JAIDS Journal of Acquired Immune Deficiency Syndromes
ISSN
(Print):
1525-4135
ISSN
(Electronic):
1944-7884
Publication date
(Print):
1
January
2017
Publication date
(Electronic):
08
December
2016
Volume: 74
Issue: Suppl 1
Pages: S69-S73
Affiliations
[*
]Centre for AIDS Development, Research and Evaluation (CADRE), Johannesburg, South
Africa; and
[†
]Centre for Communication Impact (CCI), Pretoria, South Africa.
Author notes
Correspondence to: Helen Hajiyiannis, MSocSc, Centre for AIDS Development, Research
and Evaluation (CADRE), 5th Floor, Johannesburg Chamber of Commerce and Industry Building,
27 Owl Street, Milpark, Johannesburg 2193, South Africa (e-mail:
helen@
123456cadre.org.za
).
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