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      Erratum to: Serum B cell–activating factor (BAFF) level in connective tissue disease associated interstitial lung disease

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          Abstract

          Erratum After the publication of this work [1], it was brought to the authors attention that statements in the article are not consistent with Fig. 1. The statement “Our findings show that patients who met Kinder’s criteria for UCTD had significantly higher serum BAFF levels than patients with CFIP;” and “In summary, increased levels of BAFF were found in the circulation of patients with CTD-ILD and UCTD-ILD, in whom serum levels were inversely correlated with lung function” are not a correct reflection of the results from the data analysis in Fig. 1 of the article. The corrected statements are provided here as follows: “Our findings show that patients who met Kinder’s criteria for UCTD tended to have higher serum BAFF levels than patients with CFIP;” and “In summary, increased levels of BAFF were found in the circulation of patients with CTD-ILD, in whom serum levels were inversely correlated with lung function.”

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          Serum B cell–activating factor (BAFF) level in connective tissue disease associated interstitial lung disease

          Background Interstitial lung diseases (ILDs) are common in patients with connective tissue diseases (CTDs). Although the diagnosis of an underlying CTD in ILD (CTD-ILD) affects both prognosis and treatment, it is sometimes difficult to distinguish CTD-ILD from chronic fibrosing interstitial pneumonia (CFIP). B cell–activating factor belonging to the tumour necrosis factor family (BAFF) plays a crucial role in B cell development, survival, and antibody production. Methods We examined serum levels of BAFF, surfactant protein D (SP-D), and Krebs von den Lungen-6 (KL-6) in 33 patients with CTD-ILD, 16 patients with undifferentiated CTD-ILD, 19 patients with CFIP, and 26 healthy volunteers. And we analysed the relationship between serum BAFF levels and pulmonary function, as well as the expression of BAFF in the lung tissue of patients with CTD-ILD. Results Serum levels of BAFF were significantly higher in CTD-ILD patients compared to healthy subjects and CFIP patients. However, there were no significant differences in serum levels of SP-D and KL-6. Furthermore, serum BAFF levels in CTD-ILD patients were inversely correlated with pulmonary function. BAFF was strongly expressed in the lungs of CTD-ILD patients, but weakly in normal lungs. Discussion This is the first study to demonstrate that serum BAFF levels were significantly higher in CTD-ILD patients compared to healthy subjects and CFIP patients. Furthermore, serum BAFF levels were correlated with pulmonary function. We consider that serum BAFF levels in patients with CTD-ILD reflect the presence of ILDs disease activity and severity. Conclusion These finding suggest that BAFF may be a useful marker for distinguishing CTD-ILD from CFIP.
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            Author and article information

            Contributors
            inoue-pulm@umin.net
            Journal
            BMC Pulm Med
            BMC Pulm Med
            BMC Pulmonary Medicine
            BioMed Central (London )
            1471-2466
            8 August 2016
            8 August 2016
            2016
            : 16
            : 117
            Affiliations
            [1 ]Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520 Japan
            [2 ]Department of Molecular and Cellular Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
            [3 ]Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan
            Article
            278
            10.1186/s12890-016-0278-1
            4977676
            27501722
            352daae2-9209-4caa-9c30-c294402f64a2
            © The Author(s). 2016

            Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

            History
            : 18 July 2016
            : 2 August 2016
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            Erratum
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            © The Author(s) 2016

            Respiratory medicine
            Respiratory medicine

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