Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

In this study, we elucidated the differential expression of a set of local molecular factors in ectatic cone area of the cornea to uncover a functional cause for focal corneal weakening characteristic of the keratoconus (KC) disease.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Oct 01 2016

Volume: 57

Issue: 13

Affiliations

[1 ] Cornea Department, Narayana Nethralaya, Bangalore, India.

[2 ] GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India.

[3 ] Cornea Clinic, Department of Ophthalmology, Maastricht University Medical Center, the Netherlands.

[4 ] Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States.

[5 ] Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States 5Mason Eye Institute, School of Medicine, University of Missouri, Columbia, Missouri, United States 6Harry S. Truman Veterans' Memorial Hospital, Columbia, Missouri, United States.

[6 ] GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, India 7Singapore Eye Research Institute, Singapore.

Article

Publisher Item ID: 2569562

DOI: 10.1167/iovs.16-19677

PubMed ID: 27732724

SO-VID: 321e6c2d-a75f-465f-9af3-b3b36677f027

History

Data availability:

Comments

Comment on this article

scite_

Cited by 50

See all cited by