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Hydrophilic chlorin-conjugated magnetic nanoparticles—Potential anticancer agent for the treatment of melanoma by PDT
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Abstract
This Letter reports the synthesis and the characterization of two new water-stable
and soluble photosensitizer-conjugated magnetic nanoparticles (PS-MNPs) composed of
an iron oxide magnetic core coated with a biocompatible dextran shell bearing polyaminated
chlorin p6. Designed to improve cancer cell targeting, these photosensitizers were
assayed for their antitumour activity against two variants of B16 mouse melanoma cell
line (B16F10 and B16G4F, with or without melanin, respectively). Cell viability measurements
demonstrated that PS-MNPs were more phototoxic than PEI-chlorin p6 making these photosensitizers
promising for further in vitro and in vivo investigations.