Left ventricular assist systems and infection-related outcomes: A comprehensive analysis of the MOMENTUM 3 trial.

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Abstract

In a randomized controlled trial (MOMENTUM 3), the HeartMate 3 (HM3) fully magnetically levitated centrifugal-flow left ventricular assist device (LVAD) demonstrated superiority over the HeartMate II (HMII) axial-flow LVAD. These findings were driven by hemocompatibility-related outcomes, but infection-related outcomes were not altered by device choice. In this trial-level analysis, we analyzed the clinical patterns of infection-related outcomes over 2 years of support.

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Journal

Journal ID (iso-abbrev): J Heart Lung Transplant

Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publisher: Elsevier BV

ISSN (Electronic): 1557-3117

ISSN (Print): 1053-2498

Publication date (Electronic): August 2020

Volume: 39

Issue: 8

Affiliations

[1 ] Duke University Medical Center, Durham, North Carolina.

[2 ] New York-Presbyterian/Columbia University Medical Center, New York, New York.

[3 ] Allegheny General Hospital, Pittsburgh, Pennsylvania.

[4 ] Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

[5 ] University of Minnesota Medical Center, Minneapolis, Minnesota.

[6 ] Mission Health System, Asheville, North Carolina.

[7 ] University of Colorado School of Medicine, Aurora, Colorado.

[8 ] Montefiore Einstein Center for Heart and Vascular Care, New York, New York.

[9 ] Abbott, Abbott Park, Illinois.

[10 ] Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: mmehra@bwh.harvard.edu.

Article

Publisher Item ID: S1053-2498(20)31428-5

DOI: 10.1016/j.healun.2020.03.002

PubMed ID: 32276809

SO-VID: 2ff812f1-e6d0-4679-baf0-d45bfa01b370

History

Keywords: LVAD,MCS,driveline,heart failure,infection,prognosis

Data availability:

Keywords: LVAD, MCS, driveline, heart failure, infection, prognosis

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