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      A case of lipomatous pleomorphic adenoma in the parotid gland: a case report

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      1 ,
      Diagnostic Pathology
      BioMed Central

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          Abstract

          Introduction

          Pleomorphic adenoma is the most common benign neoplasm of the salivary glands. Extensive lipomatous involvement of the tumor is, however, a very rare finding.

          Case report

          Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.

          Conclusion

          This is the sixth case of lipomatous pleomorphic adenoma in the English literature. Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management. On CT scan, it may not be detected possibly due to the extensive fatty component.

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          Most cited references5

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          Lipomatous pleomorphic adenoma of the parotid gland. Classification of lipomatous tissue in salivary glands.

          Lipomatous pleomorphic adenoma is an unusual subtype with a lipomatous stromal component of more than 90% of the tumour tissue. This special type of pleomorphic adenoma must be distinguished from other types of lipomatous tumours or non-tumourous lipomatosis of the salivary glands. Until now only two cases of lipomatous pleomorphic adenoma have been reported in the literature. We report of a 36-year old woman who developed a well circumscribed nodule measuring 3.5 x 2.5 x 2 cm in the right parotid gland. The cut surface was grey-yellowish. Histologically, more than 90% of the tumour tissue was fatty tissue with univacuolar adipocytes. The pleomorphic epithelial elements were duct-like cells forming small lumina and spindle-shaped myoepithelial cell with surrounding mucoid stroma. Components of pleomorphic adenoma were intermingled with mature adipose tissue which was more concentrated in the central portion of the adenoma. Some compressed epithelial cords in the adipose tissue formed a septa-like pattern. The differential diagnosis to other lipomatous tumours (lipoadenoma, lipoma) and to non-tumourous interstitial lipomatosis as well as the possible pathogenesis as metaplastic change or epithelial-mesenchymal transdifferentiation are discussed.
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            Myxolipomatous pleomorphic adenoma: an unusual oral presentation.

            The first case of a myxoid variant of lipomatous pleomorphic adenoma arising in the intraoral minor salivary gland is presented. A well-encapsulated tumor was composed almost entirely of myxolipomatous tissue with honeycomb-like spindled cellular areas, which contained only a scant glandular element. Immunohistochemistry confirmed the myoepithelial nature of spindle cells intimately admixed with mucoadipose component. We propose the term myxolipomatous pleomorphic adenoma for this peculiar lesion.
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              Pleomorphic adenoma with extensive lipometaplasia.

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                Author and article information

                Journal
                Diagn Pathol
                Diagnostic Pathology
                BioMed Central
                1746-1596
                2009
                4 June 2009
                : 4
                : 16
                Affiliations
                [1 ]Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
                Article
                1746-1596-4-16
                10.1186/1746-1596-4-16
                2710317
                19497106
                2f87aec3-5b8b-4888-84b6-3477e9557dd9
                Copyright © 2009 Kondo; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 30 March 2009
                : 4 June 2009
                Categories
                Case Report

                Pathology
                Pathology

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