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      Juvenile pleomorphic adenoma of the cheek: a case report and review of literature

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      1 , , 2
      Diagnostic Pathology
      BioMed Central

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          Abstract

          Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands. About 90% of these tumors occur in the parotid gland and 10% in the minor salivary glands. The most common sites of pleomorphic adenoma of the minor salivary glands are the palates followed by lips and cheeks. Other rare sites include the throat, floor of the mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity. In children, intraoral pleomorphic adenomas of the cheek are extremely rare with only three cases reported to date. Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 17-year-old girl. The mass was removed by wide local excision with adequate margins, and after a follow-up period of three years there were no recurrences. To conclude, pleomorphic adenoma should be considered in the differential diagnosis of cheek masses in youngsters. Wide local excision is to be recommended as the treatment of choice. A close follow-up is necessary postoperatively.

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          Most cited references22

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          Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases.

          This study aimed to investigate the diverse histopathological types and distribution characteristics of epithelial minor salivary gland tumors (MSGTs) in a Chinese population. We conducted a descriptive demographic study of 737 intraoral MSGTs in patients in southwest China from 1990 to 2004. A total of 737 epithelial MSGTs, consisting of 340 (46.1%) benign and 397 (53.9%) malignant tumors, were confirmed in 381 males and 356 females. The average age of patients with benign and malignant tumors was 40.7 and 49.4 years, respectively. The palate was the most commonly affected site (67.4%). Pleomorphic adenoma (PA) (81.8%) and adenoid cystic carcinoma (ACC) (36.0%) were the most frequent types in benign and malignant tumors, respectively. Comparing with reports from other countries, it is suggested that the MSGTs in this southwest Chinese population may be characterized by a higher incidence of MSGTs than in the other reviewed countries, higher incidence of malignant than benign MSGTs, absence of canalicular adenoma (CA) occurrence, and a higher incidence of myoepithelioma (MEO).
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            Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases.

            We present a retrospective study of 82 patients with intraoral minor salivary gland tumors which were diagnosed from 1979 to 2003 in Gifu University Hospital. The histological diagnoses were reevaluated according to the 1991 WHO classification. A total of 82 tumors, consisting of 55 benign and 27 malignant tumors, were found in 28 male and 54 female Japanese patients; the male-to-female ratio was 1:1.9. The mean age of the patients was 51.4+/-18.1 years. The tumors affected the palate (n = 64), the buccal region (n = 10), the upper lip (n = 6), the floor of the mouth (n = 1), and the retromolar region (n = 1). Histologically, the tumors were classified as pleomorphic adenoma (n = 54), papillary cystadenoma (n = 1), adenoid cystic carcinoma (n = 10), mucoepidermoid carcinoma (n = 8), acinic cell carcinoma (n = 3), adenocarcinoma (n = 2), basal cell adenocarcinoma (n = 1), papillary cystadenocarcinoma (n = 1), and carcinoma in pleomorphic adenoma (n = 2). From the results of the present study and review of the literature, it is suggested that the minor salivary gland tumors in Japan may be characterized by a higher incidence of benign tumors, especially of pleomorphic adenoma; a more marked tendency for female predominance; a higher incidence of palatal involvement; and a rarer occurrence of polymorphous low grade adenocarcinoma, in comparison with those reported in the literature from outside of Japan.
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              Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature.

              The aim of this study is to report on five cases of intraoral pleomorphic adenoma (PA) in patients under 18 years of age and to review the literature. Intraoral salivary gland tumours were reviewed in two Brazilian institutions and five cases of PA in patients under 18 years of age were found. Clinical data were obtained from the medical records and paraffin-embedded tissues were sectioned for proliferating cell nuclear antigen (PCNA) and p53 immunohistochemical analysis. Four patients were female and one was male; two cases affected the palate, two the upper lip and one the tongue. All five patients were treated surgically and after long follow-up periods no recurrences were observed. Tumour cells were weakly positive for PCNA and negative for p53. PA should be considered in the differential diagnosis of submucosal nodules in young patients. In youngsters, PA seems to have similar biological characteristics as in adults, with low recurrence rates after surgical resection.
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                Author and article information

                Journal
                Diagn Pathol
                Diagnostic Pathology
                BioMed Central
                1746-1596
                2009
                22 September 2009
                : 4
                : 32
                Affiliations
                [1 ]Department of Oral & Maxillofacial surgery, Faculty of Dentistry, Damascus University Hospitals, Damascus, Syria
                [2 ]Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
                Article
                1746-1596-4-32
                10.1186/1746-1596-4-32
                2759908
                19772659
                a35f1076-d0f0-4474-8821-8aa6d2f5ec6a
                Copyright © 2009 Dalati and Hussein; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 15 May 2009
                : 22 September 2009
                Categories
                Case Report

                Pathology
                Pathology

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