Shedding light on biology and healthcare—preface to the special issue on Biomedical Optics

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Abstract

This special issue collects 20 excellent papers, spanning NIR II imaging, high-speed imaging, adaptive wavefront shaping, label-free imaging, ultrasensitive detection, polarization optics, photodynamic therapy, and preclinical applications.

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Polarisation optics for biomedical and clinical applications: a review

Chao He, Honghui He, Jintao Chang … (2021)

Many polarisation techniques have been harnessed for decades in biological and clinical research, each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by objects. Various advanced vector measurement/sensing techniques, physical interpretation methods, and approaches to analyse biomedically relevant information have been developed and harnessed. In this review, we focus mainly on summarising methodologies and applications related to tissue polarimetry, with an emphasis on the adoption of the Stokes–Mueller formalism. Several recent breakthroughs, development trends, and potential multimodal uses in conjunction with other techniques are also presented. The primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research. The review focuses on methodologies and biomedical applications of polarisation optics. It also presents prospects on development trends, the potential multi-modal uses in conjunction with other techniques.

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Perfecting and extending the near-infrared imaging window

Zhe Feng, Tao Tang, Tianxiang Wu … (2021)

In vivo fluorescence imaging in the second near-infrared window (NIR-II) has been considered as a promising technique for visualizing mammals. However, the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be perfected. Herein, we simulate the photon propagation in the NIR region (to 2340 nm), confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-II window as 900–1880 nm, where 1400–1500 and 1700–1880 nm are defined as NIR-IIx and NIR-IIc regions, respectively. Moreover, 2080–2340 nm is newly proposed as the third near-infrared (NIR-III) window, which is believed to provide the best imaging quality. The wide-field fluorescence microscopy in the brain is performed around the NIR-IIx region, with excellent optical sectioning strength and the largest imaging depth of intravital NIR-II fluorescence microscopy to date. We also propose 1400 nm long-pass detection in off-peak NIR-II imaging whose performance exceeds that of NIR-IIb imaging, using bright fluorophores with short emission wavelength. Moderate light absorption by bio-tissue is conducive to the imaging performance. The second near-infrared window is perfected as 900–1880 nm, and 2080–2340 nm is proposed as the third near-infrared window.

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Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs

Lanhua Liu, Xuejun Zhang, Qian Zhu … (2021)

The apparent increase in hormone-induced cancers and disorders of the reproductive tract has led to a growing demand for new technologies capable of detecting endocrine disruptors. However, a long-lasting challenge unaddressed is how to achieve ultrahigh sensitive, continuous, and in situ measurement with a portable device for in-field and remote environmental monitoring. Here we demonstrate a simple-to-implement plasmonic optical fiber biosensing platform to achieve an improved light–matter interaction and advanced surface chemistry for ultrasensitive detection of endocrine disruptors. Our platform is based on a gold-coated highly tilted fiber Bragg grating that excites high-density narrow cladding mode spectral combs that overlap with the broad absorption of the surface plasmon for high accuracy interrogation, hence enabling the ultrasensitive monitoring of refractive index changes at the fiber surface. Through the use of estrogen receptors as the model, we design an estradiol–streptavidin conjugate with the assistance of molecular dynamics, converting the specific recognition of environmental estrogens (EEs) by estrogen receptor into surface-based affinity bioassay for protein. The ultrasensitive platform with conjugate-induced amplification biosensing approach enables the subsequent detection for EEs down to 1.5 × 10 −3 ng ml −1 estradiol equivalent concentration level, which is one order lower than the defined maximal E 2 level in drinking water set by the Japanese government. The capability to detect EEs down to nanogram per liter level is the lowest limit of detection for any estrogen receptor-based detection reported thus far. Its compact size, flexible shape, and remote operation capability open the way for detecting other endocrine disruptors with ultrahigh sensitivity and in various hard-to-reach spaces, thereby having the potential to revolutionize environment and health monitoring. An optical fiber biosensor displaying superfine plasmonic spectral combs and enhanced by conjugate-induced amplification enables the detection of environmental estrogens down to pg/mL estradiol equivalent concentration level.

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Author and article information

Contributors

Peng Xi:

ORCID: http://orcid.org/0000-0001-6626-4840

xipeng@pku.edu.cn

Journal

Journal ID (nlm-ta): Light Sci Appl

Journal ID (iso-abbrev): Light Sci Appl

Title: Light, Science & Applications

Publisher: Nature Publishing Group UK (London )

ISSN (Print): 2095-5545

ISSN (Electronic): 2047-7538

Publication date (Electronic): 2 June 2022

Publication date PMC-release: 2 June 2022

Publication date Collection: 2022

Volume: 11

Electronic Location Identifier: 156

Affiliations

[1 ]GRID grid.11135.37, ISNI 0000 0001 2256 9319, Department of Biomedical Engineering, College of Future Technology, , Peking University, ; 100871 Beijing, China

[2 ]GRID grid.11135.37, ISNI 0000 0001 2256 9319, Department of Biomedical Engineering, , Peking University, ; 100081 Beijing, China

[3 ]GRID grid.263488.3, ISNI 0000 0001 0472 9649, Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of Education, , Shenzhen University, ; 518060 Shenzhen, China

[4 ]GRID grid.446088.6, ISNI 0000 0001 2179 0417, Saratov State University, ; 83 Astrakhanskaya str., Saratov, 410012 Russia

Author information

Peng Xi http://orcid.org/0000-0001-6626-4840

Junle Qu http://orcid.org/0000-0001-7833-4711

Valery V. Tuchin http://orcid.org/0000-0001-7479-2694

Article

Publisher ID: 804

DOI: 10.1038/s41377-022-00804-w

PMC ID: 9160079

SO-VID: 2ef046d3-3009-474d-9316-e44869d92663

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 15 April 2022

Date accepted : 15 April 2022

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Keywords: optics and photonics,biophotonics

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Keywords: optics and photonics, biophotonics

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Shedding light on biology and healthcare—preface to the special issue on Biomedical Optics

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Abstract

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Electrospinning for biomedical applications

Most cited references 22

Polarisation optics for biomedical and clinical applications: a review

Perfecting and extending the near-infrared imaging window

Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs

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