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      The DSM-5 criteria, level of arousal and delirium diagnosis: inclusiveness is safer

      research-article
      European Delirium Association, American Delirium Society
      BMC Medicine
      BioMed Central
      Delirium, Consciousness, Arousal, Attention, Diagnostic and Statistical Manual of Mental Disorders

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          Abstract

          Background

          Delirium is a common and serious problem among acutely unwell persons. Alhough linked to higher rates of mortality, institutionalisation and dementia, it remains underdiagnosed. Careful consideration of its phenomenology is warranted to improve detection and therefore mitigate some of its clinical impact. The publication of the fifth edition of the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-5) provides an opportunity to examine the constructs underlying delirium as a clinical entity.

          Discussion

          Altered consciousness has been regarded as a core feature of delirium; the fact that consciousness itself should be physiologically disrupted due to acute illness attests to its clinical urgency. DSM-5 now operationalises ‘consciousness as ‘changes in attention . It should be recognised that attention relates to content of consciousness, but arousal corresponds to level of consciousness. Reduced arousal is also associated with adverse outcomes. Attention and arousal are hierarchically related; level of arousal must be sufficient before attention can be reasonably tested.

          Summary

          Our conceptualisation of delirium must extend beyond what can be assessed through cognitive testing (attention) and accept that altered arousal is fundamental. Understanding the DSM-5 criteria explicitly in this way offers the most inclusive and clinically safe interpretation.

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          Most cited references6

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          ViEWS--Towards a national early warning score for detecting adult inpatient deterioration.

          To develop a validated, paper-based, aggregate weighted track and trigger system (AWTTS) that could serve as a template for a national early warning score (EWS) for the detection of patient deterioration. Using existing knowledge of the relationship between physiological data and adverse clinical outcomes, a thorough review of the literature surrounding EWS and physiology, and a previous detailed analysis of published EWSs, we developed a new paper-based EWS - VitalPAC EWS (ViEWS). We applied ViEWS to a large vital signs database (n=198,755 observation sets) collected from 35,585 consecutive, completed acute medical admissions, and also evaluated the comparative performance of 33 other AWTTSs, for a range of outcomes using the area under the receiver-operating characteristics (AUROC) curve. The AUROC (95% CI) for ViEWS using in-hospital mortality with 24h of the observation set was 0.888 (0.880-0.895). The AUROCs (95% CI) for the 33 other AWTTSs tested using the same outcome ranged from 0.803 (0.792-0.815) to 0.850 (0.841-0.859). ViEWS performed better than the 33 other AWTTSs for all outcomes tested. We have developed a simple AWTTS - ViEWS - designed for paper-based application and demonstrated that its performance for predicting mortality (within a range of timescales) is superior to all other published AWTTSs that we tested. We have also developed a tool to provide a relative measure of the number of "triggers" that would be generated at different values of EWS and permits the comparison of the workload generated by different AWTTSs. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
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            In-hospital mortality and morbidity of elderly medical patients can be predicted at admission by the Modified Early Warning Score: a prospective study.

            Although early warning scores were originally derived as bedside tools for alerting the medical staff, they may serve as decision rules for the admission of medical patients. We conducted this study to investigate the ability of the Modified Early Warning Score (MEWS) to identify a subset of patients at risk of deterioration, who might benefit from an increased level of attention. Prospective, single centre, cohort study. A 64-bedded medical ward in a public, non-teaching Hospital in Italy. All patients consecutively admitted from 15th November 2005 to 9th June 2006. On admission, the attending physician measured five physiological parameters (systolic blood pressure, pulse rate, respiratory rate, body temperature and level of consciousness) and calculated the MEWS. The main outcome measures were in-hospital mortality and a composite of mortality and transfer to a higher level of care. A secondary end-point was the length of stay for discharged patients. In all, 1107 patients were admitted; 621 (56.1%) were women and 486 were men. Patients of female gender were also older (mean age 80.6 years) than men (mean age 77.1; p < 0.05). Of 1107, 995 patients (89.9%) were older than 64 years. A total of 966 patients were discharged, 102 deceased and 39 were transferred. In comparison with the lowest score, the risk of death was incremental among all the MEWS categories, as well as the risk of the combined outcome of death and transfer, and highly significant (risk of death, chi(2) for trend 136.307; risk of death or transfer, chi(2) for trend 105.762; p < 0.00001 for both). Patients with MEWS < or = 4 were discharged after a mean stay of 8.3 days, and alive patients with MEWS of five or more were discharged after a mean stay of 9.4 days (p = ns). A patient with a MEWS of zero at admission has a very low probability to die or to be transferred because of clinical instability (OR 0.14, 95% CI: 0.08-0.24). We have confirmed that the MEWS, even when calculated once on admission, is a simple but highly useful tool to predict a worse in-hospital outcome.
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              Who understands delirium?

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                Author and article information

                Contributors
                daniel.davis@ucl.ac.uk
                Journal
                BMC Med
                BMC Med
                BMC Medicine
                BioMed Central (London )
                1741-7015
                25 September 2014
                25 September 2014
                2014
                : 12
                : 1
                : 141
                Affiliations
                MRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London, WC1B 5JU UK
                Article
                141
                10.1186/s12916-014-0141-2
                4177077
                25300023
                2da74c4f-074f-4620-9eec-5029d6d8ae81
                © European Delirium Association et al.; licensee BioMed Central Ltd. 2014

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 30 April 2014
                : 1 August 2014
                Categories
                Opinion
                Custom metadata
                © The Author(s) 2014

                Medicine
                delirium,consciousness,arousal,attention,diagnostic and statistical manual of mental disorders

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