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Abstract
Conducting PK studies in pregnant women is challenging. Therefore, we asked if a physiologically-based
pharmacokinetic (PBPK) model could be used to predict the disposition in pregnant
women of drugs cleared by multiple CYP enzymes.
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Department of Pharmaceutics, University of Washington, Seattle, WA, USA; Office of
Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation
and Research, Food and Drug Administration, Silver Spring, MD, USA.