For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
12
views
38
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      147
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Efficacy and safety of platelet-rich plasma for acute nonarteritic anterior ischemic optic neuropathy: a prospective cohort study

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          As the most common acute optic neuropathy in older patients, nonarteritic anterior ischemic optic neuropathy (NAION) presents with varying degrees of visual acuity loss and visual field defect. However, there is no generally accepted treatment for NAION.

          Objectives

          To evaluate the efficacy and safety of platelet-rich plasma (PRP) for patients with acute NAION within 2 months.

          Design

          A prospective, nonrandomized controlled trial.

          Methods

          Twenty-five eyes of 25 patients were enrolled. Of them, 13 received anisodine hydrobromide and butylphthalide-sodium chloride injection continuously for 10 days as basic treatment in the control group, and 12 received two tenon capsule injections of PRP on a 10 days interval as an additional treatment in the PRP group. We compared the best-corrected visual acuity (BCVA) and capillary perfusion density (CPD) of radial peripapillary capillaries and the moth-eaten eara of the peripapillary superficial capillary plexus and deep capillary plexus at 1 day (D1) before the first PRP treatment and 7 days (D7), 14 days (D14), and 30 days (D30) after the first PRP injection. Ocular and systemic adverse effects were assessed.

          Results

          In the PRP group, a better BCVA occurred at D30 (adjusted p = 0.005, compared with D1, recovered from 0.67 ± 0.59 to 0.43 ± 0.59), and a significant improvement in CPD was observed at D30 (adjusted p < 0.001, p = 0.027, p = 0.027, compared with D1, D7, D14, in sequence, the value was 35.97 ± 4.65, 38.73 ± 4.61, 39.05 ± 5.26, 42.71 ± 4.72, respectively). CPD at D7 in the PRP group was better than that in the control group ( p = 0.043). However, neither BCVA nor the moth-eaten area index were significantly different (all p > 0.5) between the two groups. The main adverse effect was local discomfort resolved within 1 week, and no other systemic adverse events occurred.

          Conclusion

          Tenon capsule injection of PRP was a safe treatment for AION and could improve capillary perfusion of the optic nerve head and might be helpful in increasing short-term vision in patients with acute NAION.

          Related collections

          Most cited references38

          • Record: found
          • Abstract: not found
          • Article: not found

          Ischemic Optic Neuropathies.

          Valérie Biousse, Nancy Newman (2015)
          Article 0 comments Cited 85 times – based on 0 reviews     Review now
          Article has an altmetric score of 30
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Platelet-Rich Plasma.

            Peter Wu, Robert Díaz, Joanne Borg-Stein (2016)
            Platelet-rich plasma (PRP) is a growing and robust therapeutic option in musculoskeletal medicine. PRP is a preparation of autologous plasma enriched with a platelet concentration above that normally contained in whole blood. The rationale for use and therapeutic potential of a high concentration of platelets is based on their capacity to supply supraphysiologic amounts of essential growth factors to provide a regenerative stimulus that promotes repair in tissues with low healing potential. This article reviews the latest basic science on PRP, clinical evidence for its use in musculoskeletal medicine, limitations in current knowledge, and critical areas for future research.
            Article 0 comments Cited 81 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Incidence of nonarteritic anterior ischemic optic neuropathy.

              M G Hattenhauer, J A Leavitt, D O Hodge … (1997)
              Nonarteritic anterior ischemic optic neuropathy is the most common acute optic nerve disease of adults over age 50 years. This study determined the incidence of acute nonarteritic anterior ischemic optic neuropathy in the circumscribed population of Olmsted County, Minnesota. This was a retrospective study of the incidence of acute nonarteritic anterior ischemic optic neuropathy between 1981 and 1990. The Rochester Epidemiology Project medical records linkage system facilitates identification of the medical records of virtually all Olmsted County residents with a given diagnosis. All cases of acute nonarteritic anterior ischemic optic neuropathy that fulfilled certain inclusion and exclusion criteria were identified. Twenty-two cases in 21 patients (11 men and 10 women) were recorded. The crude annual incidence rate was 10.3 per 100,000 individuals (95% confidence interval [CI] = 5.1 to 18.4). When adjusted to the age and sex distribution of the 1990 United States white population, the incidence rate was 10.2 per 100,000 (95% CI = 6.5 to 15.6). At diagnosis, the median age was 72 years, mean visual acuity was 20/200 in the affected eye, and the most common visual field defect was an altitudinal deficit (10 cases). Although results of this small study should be interpreted cautiously, extrapolation of our findings to the United States white population indicates that nearly 5,700 new cases of acute nonarteritic anterior ischemic optic neuropathy may be expected to occur each year in this group.
              Article 0 comments Cited 69 times – based on 0 reviews     Review now
              Article has an altmetric score of 18
                Bookmark
                All references

                Author and article information

                Contributors
                Xin Jin: URI : https://loop.frontiersin.org/people/2581629/overviewRole: Role: Role: Role: Role:
                Junxia Fu: URI : https://loop.frontiersin.org/people/2618103/overviewRole: Role: Role:
                Ruju Lv: Role: Role:
                Xiaolu Hao: Role: Role: Role:
                Song Wang: Role: Role:
                Mingming Sun: URI : https://loop.frontiersin.org/people/1067862/overviewRole: Role:
                Guangcan Xu: Role: Role: Role: Role:
                Qi Zhang: Role: Role:
                Lei Zhang: Role: Role:
                Yan Li: Role: Role:
                Baoke Hou: URI : https://loop.frontiersin.org/people/398899/overviewRole: Role: Role: Role: Role:
                Journal
                Journal ID (nlm-ta): Front Med (Lausanne)
                Journal ID (iso-abbrev): Front Med (Lausanne)
                Journal ID (publisher-id): Front. Med.
                Title: Frontiers in Medicine
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2296-858X
                Publication date (Electronic): 13 March 2024
                Publication date Collection: 2024
                Volume: 11
                Electronic Location Identifier: 1344107
                Affiliations
                [1] 1Senior Department of Ophthalmology, The Third Medical Center of PLA General Hospital , Beijing, China
                [2] 2Department of Ophthalmology, School of Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University , Shanghai, China
                [3] 3Department of Ophthalmology, Jinan University , Jinan, China
                [4] 4Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University , Hefei, China
                Author notes

                Edited by: Georgios D. Panos, Nottingham University Hospitals NHS Trust, United Kingdom

                Reviewed by: Zizhong Hu, Nanjing Medical University, China

                Xiaofei Wang, Beihang University, China

                *Correspondence: Quangang Xu, xuquangang@ 123456126.com

                †These authors have contributed equally to this work

                ‡ORCID: Xin Jin, https://orcid.org/0000-0001-9344-7976

                Junxia Fu, https://orcid.org/0000-0001-8965-4577

                Song Wang, https://orcid.org/0009-0004-3683-4557

                Quangang Xu, https://orcid.org/0000-0002-4507-1377

                Baoke Hou, https://orcid.org/0009-0003-5035-5678

                Article
                DOI: 10.3389/fmed.2024.1344107
                PMC ID: 10993780
                PubMed ID: 38576708
                SO-VID: 2c87c5c9-f3c7-4478-81fd-e2d38e12cb8b
                Copyright © Copyright © 2024 Jin, Fu, Lv, Hao, Wang, Sun, Xu, Zhang, Zhang, Li, Xu and Hou.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 25 November 2023
                Date accepted : 01 February 2024
                Page count
                Figures: 3, Tables: 4, Equations: 0, References: 38, Pages: 9, Words: 6365
                Funding
                The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
                Categories
                Subject: Medicine
                Subject: Original Research
                Custom metadata
                section-at-acceptance Ophthalmology

                Keywords: platelet-rich plasma,nonarteritic anterior ischemic optic neuropathy,prospective controlled trial,oct angiography,efficacy and safety analyses
                Data availability:
                Keywords: platelet-rich plasma, nonarteritic anterior ischemic optic neuropathy, prospective controlled trial, oct angiography, efficacy and safety analyses

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content147

                See all similar

                Most referenced authors334

                See all reference authors