Platelet-Rich Plasma.

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Abstract

Platelet-rich plasma (PRP) is a growing and robust therapeutic option in musculoskeletal medicine. PRP is a preparation of autologous plasma enriched with a platelet concentration above that normally contained in whole blood. The rationale for use and therapeutic potential of a high concentration of platelets is based on their capacity to supply supraphysiologic amounts of essential growth factors to provide a regenerative stimulus that promotes repair in tissues with low healing potential. This article reviews the latest basic science on PRP, clinical evidence for its use in musculoskeletal medicine, limitations in current knowledge, and critical areas for future research.

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Author and article information

Journal

Journal ID (iso-abbrev): Phys Med Rehabil Clin N Am

Title: Physical medicine and rehabilitation clinics of North America

Publisher: Elsevier BV

ISSN (Electronic): 1558-1381

ISSN (Print): 1047-9651

Publication date (Electronic): Nov 2016

Volume: 27

Issue: 4

Affiliations

[1 ] Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, 300 First Avenue, Charlestown, MA 02129, USA. Electronic address: iwu3@partners.org.

[2 ] Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, 300 First Avenue, Charlestown, MA 02129, USA.

[3 ] Department of Physical Medicine & Rehabilitation, Newton-Wellesley Hospital Spine Center, Spaulding Rehabilitation Hospital, Harvard Medical School, 65 Walnut Street, Wellesley, MA 02481, USA.

Article

Publisher Item ID: S1047-9651(16)30043-2

DOI: 10.1016/j.pmr.2016.06.002

PubMed ID: 27788903

SO-VID: 05fa7d61-4b88-4e81-960b-78c90f51395d

History

Keywords: Healing,Injection,Musculoskeletal,Platelet-rich plasma,Regenerative,Rehabilitation,Sports

Data availability:

Keywords: Healing, Injection, Musculoskeletal, Platelet-rich plasma, Regenerative, Rehabilitation, Sports

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