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      Geometric properties of crumpled wires and the condensed non-solid packing state of very long molecular chains

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          Abstract

          Geometric aspects associated with the hierarchical and heterogeneous packing of crumpled wires are reviewed. The recently discovered phenomenon of condensation of elastic energy of curvature in these structures is discussed, and new results are presented with emphasis on robust scaling laws. It is examined the possible relevance of these laws in the conformational properties of long molecular chains densely packaged in a non-solid state, as e.g. in the packing of DNA strands in chromosomes, or in virus capsids. In particular, mean field arguments are used to estimate the dependence of the number of loops in the dense non-solid packed three-dimensional configurations of a very long polymer strand as a function of the number of monomers or the chain length.

          Translated abstract

          Aspectos geométricos associados com o empacotamento hierárquico e heterogêneo de arames amassados são revistos. O fenômeno recentemente descoberto de condensação de energia elástica de curvatura nessas estruturas é discutido e novos resultados são apresentados, com ênfase em leis de escala robustas. Examina-se a possível relevância destas leis nas propriedades conformacionais de cadeias moleculares longas e densamente empacotadas em estado não-sólido como observado, por exemplo, para o DNA nos cromossomas ou nas cápsulas virais. Em particular, argumentos de campo médio são usados para estimar a dependência entre o número de laços e o comprimento dessas cadeias.

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          Protein targeting to ATP-dependent proteases.

          ATP-dependent proteases control diverse cellular processes by degrading specific regulatory proteins. Recent work has shown that protein substrates are specifically transferred to ATP-dependent proteases through different routes. These routes can function in parallel or independently. In all of these targeting mechanisms, it can be useful to separate two steps: substrate binding to the protease and initiation of degradation.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                jbchs
                Journal of the Brazilian Chemical Society
                J. Braz. Chem. Soc.
                Sociedade Brasileira de Química (São Paulo )
                1678-4790
                2008
                : 19
                : 2
                : 293-298
                Affiliations
                [1 ] Universidade Federal de Pernambuco Brazil
                [2 ] Universidade Federal do Piauí Brazil
                Article
                S0103-50532008000200014
                10.1590/S0103-50532008000200014
                2c215d65-7288-4a1a-87a6-7c568c6b4dc2

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0103-5053&lng=en
                Categories
                CHEMISTRY, MULTIDISCIPLINARY

                General chemistry
                crumpled wire,scale invariance,DNA packing
                General chemistry
                crumpled wire, scale invariance, DNA packing

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