Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

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Abstract

Finding innovative solutions to improve the lives of people affected by trauma, bone disease, or aging continues to be a challenge worldwide. Tissue engineering is the most rapidly growing area in the domain of biomaterials. Cerium-containing MBG-derived biomaterials scaffolds were synthesized using polymethyl methacrylate (PMMA) as a sacrificial template. The obtained scaffolds were characterized by X-ray powder diffraction (XRPD), infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The Ce4+/Ce3+ ratio in the scaffolds was estimated. In vitro testing revealed good cytocompatibility of the investigated scaffolds in mouse fibroblast cell line (NCTC clone L929). The results obtained regarding bioactivity, antibacterial activity, and controlled drug delivery functions recommend these scaffolds as potential candidates for bone tissue engineering applications.

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Bone grafts and biomaterials substitutes for bone defect repair: A review

Wenhao Wang, Kelvin W.K. Yeung (2017)

Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered. Although clinical applications of these factors have exhibited good bone formation, their further application was limited due to high cost and potential adverse side effects. Alternatively, bioinorganic ions such as magnesium, strontium and zinc are considered as alternative of osteogenic biological factors. Hence, this paper aims to review the currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect.

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Author and article information

Contributors

Irina Atkinson: (View ORCID Profile)

Daniela Culita: (View ORCID Profile)

Oana Catalina Mocioiu: (View ORCID Profile)

Raul-Augustin Mitran: (View ORCID Profile)

Daniel Lincu: (View ORCID Profile)

Oana Craciunescu: (View ORCID Profile)

Journal

Journal ID (publisher-id): PHARK5

Title: Pharmaceutics

Abbreviated Title: Pharmaceutics

Publisher: MDPI AG

ISSN (Electronic): 1999-4923

Publication date Created: June 2022

Publication date (Electronic): May 30 2022

Volume: 14

Issue: 6

Page: 1169

Article

DOI: 10.3390/pharmaceutics14061169

PubMed ID: 35745741

SO-VID: 27960d60-69b8-4405-b139-48f93bd57211

License:

https://creativecommons.org/licenses/by/4.0/

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