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      The potential use of digital health technologies in the African context: a systematic review of evidence from Ethiopia

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          Abstract

          The World Health Organization (WHO) recently put forth a Global Strategy on Digital Health 2020–2025 with several countries having already achieved key milestones. We aimed to understand whether and how digital health technologies (DHTs) are absorbed in Africa, tracking Ethiopia as a key node. We conducted a systematic review, searching PubMed-MEDLINE, Embase, ScienceDirect, African Journals Online, Cochrane Central Registry of Controlled Trials, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform databases from inception to 02 February 2021 for studies of any design that investigated the potential of DHTs in clinical or public health practices in Ethiopia. This review was registered with PROSPERO ( CRD42021240645) and it was designed to inform our ongoing DHT-enabled randomized controlled trial (RCT) (ClinicalTrials.gov ID: NCT04216420). We found 27,493 potentially relevant citations, among which 52 studies met the inclusion criteria, comprising a total of 596,128 patients, healthy individuals, and healthcare professionals. The studies involved six DHTs: mHealth (29 studies, 574,649 participants); electronic health records (13 studies, 4534 participants); telemedicine (4 studies, 465 participants); cloud-based application (2 studies, 2382 participants); information communication technology (3 studies, 681 participants), and artificial intelligence (1 study, 13,417 participants). The studies targeted six health conditions: maternal and child health (15), infectious diseases (14), non-communicable diseases (3), dermatitis (1), surgery (4), and general health conditions (15). The outcomes of interest were feasibility, usability, willingness or readiness, effectiveness, quality improvement, and knowledge or attitude toward DHTs. Five studies involved RCTs. The analysis showed that although DHTs are a relatively recent phenomenon in Ethiopia, their potential harnessing clinical and public health practices are highly visible. Their adoption and implementation in full capacity require more training, access to better devices such as smartphones, and infrastructure. DHTs hold much promise tackling major clinical and public health backlogs and strengthening the healthcare ecosystem in Ethiopia. More RCTs are needed on emerging DHTs including artificial intelligence, big data, cloud, cybersecurity, telemedicine, and wearable devices to provide robust evidence of their potential use in such settings and to materialize the WHO’s Global Strategy on Digital Health.

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            Bioprinting for the Biologist.

            Building tissues from scratch to explore entirely new cell configurations could revolutionize fundamental understanding in biology. Bioprinting is an emerging technology to do this. Although typically applied to engineer tissues for therapeutic tissue repair or drug screening, there are many opportunities for bioprinting within biology, such as for exploring cellular crosstalk or cellular morphogenesis. The overall goals of this Primer are to provide an overview of bioprinting with the biologist in mind, outline the steps in extrusion bioprinting (the most widely used and accessible technology), and discuss alternative bioprinting technologies and future opportunities for bioprinting in biology.
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              Artificial intelligence powers digital medicine

              Artificial intelligence (AI) has recently surpassed human performance in several domains, and there is great hope that in healthcare, AI may allow for better prevention, detection, diagnosis, and treatment of disease. While many fear that AI will disrupt jobs and the physician–patient relationship, we believe that AI can eliminate many repetitive tasks to clear the way for human-to-human bonding and the application of emotional intelligence and judgment. We review several recent studies of AI applications in healthcare that provide a view of a future where healthcare delivery is a more unified, human experience.
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                Author and article information

                Contributors
                tsegahunm@gmail.com
                Journal
                NPJ Digit Med
                NPJ Digit Med
                NPJ Digital Medicine
                Nature Publishing Group UK (London )
                2398-6352
                17 August 2021
                17 August 2021
                2021
                : 4
                : 125
                Affiliations
                [1 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, Addis Ababa University, College of Health Sciences, Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), ; Addis Ababa, Ethiopia
                [2 ]GRID grid.189967.8, ISNI 0000 0001 0941 6502, Emory University School of Medicine and Rollins School of Public Health, ; Atlanta, GA USA
                Author information
                http://orcid.org/0000-0002-8360-7574
                Article
                487
                10.1038/s41746-021-00487-4
                8371011
                34404895
                25fd942d-5252-4b6f-9e9b-6c1463d8ca26
                © The Author(s) 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 4 March 2021
                : 24 June 2021
                Funding
                Funded by: FundRef https://doi.org/10.13039/100000061, U.S. Department of Health & Human Services | NIH | Fogarty International Center (FIC);
                Award ID: D43TW009127
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/100008374, Emory University | Center for AIDS Research, Emory University (CFAR);
                Award ID: P30 AI050409
                Award Recipient :
                Categories
                Review Article
                Custom metadata
                © The Author(s) 2021

                health policy,translational research
                health policy, translational research

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