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      Prospective study of retention in opioid agonist treatment and contact with emergency healthcare following release from prisons in Victoria, Australia

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          Abstract

          Background

          People recently released from prison engage with emergency healthcare at greater rates than the general population. While retention in opioid agonist treatment (OAT) is associated with substantial reductions in the risk of opioid-related mortality postrelease, it is unknown how OAT affects contact with emergency healthcare. In a cohort of men who injected drugs regularly prior to imprisonment, we described rates of contact with ambulance services and EDs, and their associations with use of OAT, in the 3 months after release from prison.

          Methods

          Self-report data from a prospective observational cohort of men who regularly injected drugs before a period of sentenced imprisonment, recruited between September 2014 and May 2016, were linked to state-wide ambulance and ED records over a 3-month postrelease period in Victoria, Australia. We used generalised linear models to estimate associations between OAT use (none/interrupted/retained) and contact with ambulance and EDs postrelease, adjusted for other covariates.

          Results

          Among 265 participants, we observed 77 ambulance contacts and 123 ED contacts over a median of 98 days of observation (IQR 87–125 days). Participants who were retained in OAT between prison release and scheduled 3-month postrelease follow-up interviews had lower rates of contact with ambulance (adjusted incidence rate ratio (AIRR) 0.33, 95% CI 0.14 to 0.76) and ED (AIRR 0.43, 95% CI 0.22 to 0.83), compared with participants with no OAT use postrelease. Participants with interrupted OAT use did not differ from those with no OAT use in rates of contact with ambulance or ED.

          Conclusion

          We found lower rates of contact with emergency healthcare after release among people retained in OAT, but not among people reporting interrupted OAT use, underscoring the benefits of postrelease OAT retention. Strategies to improve accessibility and support OAT retention after leaving prison are important for men who inject drugs.

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          Most cited references41

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          Association of Opioid Agonist Treatment With All-Cause Mortality and Specific Causes of Death Among People With Opioid Dependence : A Systematic Review and Meta-analysis

          Mortality among people with opioid dependence is higher than that of the general population. Opioid agonist treatment (OAT) is an effective treatment for opioid dependence; however, there has not yet been a systematic review on the relationship between OAT and specific causes of mortality.
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            The health of prisoners.

            More than 10 million people are incarcerated worldwide; this number has increased by about a million in the past decade. Mental disorders and infectious diseases are more common in prisoners than in the general population. High rates of suicide within prison and increased mortality from all causes on release have been documented in many countries. The contribution of prisons to illness is unknown, although shortcomings in treatment and aftercare provision contribute to adverse outcomes. Research has highlighted that women, prisoners aged 55 years and older, and juveniles present with higher rates of many disorders than do other prisoners. The contribution of initiatives to improve the health of prisoners by reducing the burden of infectious and chronic diseases, suicide, other causes of premature mortality and violence, and counteracting the cycle of reoffending should be further examined. Copyright © 2011 Elsevier Ltd. All rights reserved.
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              Medication Treatment of Opioid Use Disorder

              Opioid use disorder (OUD) is a chronic, relapsing condition, often associated with legal, interpersonal, and employment problems. Medications demonstrated to be effective for OUD are methadone (a full opioid agonist), buprenorphine (a partial agonist), and naltrexone (an opioid antagonist). Methadone and buprenorphine act by suppressing opioid withdrawal symptoms and attenuating the effects of other opioids. Naltrexone blocks the effects of opioid agonists. Oral methadone has the strongest evidence for effectiveness. Longer duration of treatment allows restoration of social connections and is associated with better outcomes. Treatments for OUD may be limited by poor adherence to treatment recommendations and by high rates of relapse and increased risk of overdose after leaving treatment. Treatment with methadone and buprenorphine has the additional risk of diversion and misuse of medication. New depot and implant formulations of buprenorphine and naltrexone have been developed to address issues of safety and problems of poor treatment adherence. For people with OUD who do not respond to these treatments, there is accumulating evidence for supervised injectable opioid treatment (prescribing pharmaceutical heroin). Another medication mode of minimizing risk of overdose is take-home naloxone. Naloxone is an opioid antagonist used to reverse opioid overdose, and take-home naloxone programs aim to prevent fatal overdose. All medication-assisted treatment is limited by lack of access and by stigma. In seeking to stem the rising toll from OUD, expanding access to approved treatment such as methadone, for which there remains the best evidence of efficacy, may be the most useful approach.
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                Author and article information

                Journal
                Emerg Med J
                Emerg Med J
                emermed
                emj
                Emergency Medicine Journal : EMJ
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                1472-0205
                1472-0213
                May 2023
                9 February 2023
                : 40
                : 5
                : 347-354
                Affiliations
                [1 ] departmentDisease Elimination , Burnet Institute , Melbourne, Victoria, Australia
                [2 ] departmentSchool of Public Health and Preventive Medicine , Monash University , Melbourne, Victoria, Australia
                [3 ] departmentMonash Addiction Research Centre , Monash University , Melbourne, Victoria, Australia
                [4 ] departmentNational Drug Research Institute , Curtin University , Melbourne, Victoria, Australia
                [5 ] Victorian Institute of Forensic Medicine , Southbank, Victoria, Australia
                [6 ] departmentDepartment of Forensic Medicine , Monash University , Melbourne, Victoria, Australia
                [7 ] departmentSchool of Population Health , Curtin University , Perth, Western Australia, Australia
                [8 ] departmentSchool of Population and Global Health , University of Melbourne , Melbourne, Victoria, Australia
                [9 ] departmentCentre for Adolescent Health , Murdoch Children’s Research Institute , Melbourne, Victoria, Australia
                [10 ] departmentGriffith Criminology Institute , Griffith University , Brisbane, Queensland, Australia
                [11 ] departmentResearch & Evaluation , Ambulance Victoria , Doncaster, Victoria, Australia
                [12 ] departmentJustice Health Research Program, School of Population Health , University of New South Wales , Sydney, New South Wales, Australia
                [13 ] departmentDepartment of Gastroenterology , St Vincent's Hospital , Melbourne, Victoria, Australia
                [14 ] departmentSchool of Psychology and Public Health , La Trobe University , Melbourne, Victoria, Australia
                Author notes
                [Correspondence to ] Michael Curtis, Disease Elimination, Burnet Institute, Melbourne, Victoria, Australia; michael.curtis@ 123456burnet.edu.au
                Author information
                http://orcid.org/0000-0002-1814-0867
                http://orcid.org/0000-0003-4860-1342
                http://orcid.org/0000-0002-1579-9279
                Article
                emermed-2022-212755
                10.1136/emermed-2022-212755
                10176422
                36759173
                25f34039-1c59-4f6c-879f-cb6e3cac7138
                © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.

                This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:  https://creativecommons.org/licenses/by/4.0/.

                History
                : 05 August 2022
                : 28 January 2023
                Funding
                Funded by: Victorian Government Operational Infrastructure Support Program;
                Award ID: NA
                Funded by: Monash Addiction Research Centre;
                Award ID: NA
                Funded by: FundRef http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
                Award ID: APP1029915
                Award ID: APP1136908
                Award ID: APP1136970
                Award ID: APP1168954
                Award ID: APP2003449
                Categories
                Original Research
                1506
                Custom metadata
                unlocked

                Emergency medicine & Trauma
                drug overdoses,epidemiology,drug abuse,substance-related disorders
                Emergency medicine & Trauma
                drug overdoses, epidemiology, drug abuse, substance-related disorders

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