In red winemaking, especially those aged in wood barrels, the contamination and growth of Dekkera/Brettanomyces yeasts results in the formation of 4-ethylphenol (4-EP) and 4-ethylguaiacol (4-EG). These volatile phenols (VPs) are responsible for negative aromatic notes like horsy, barnyard, smoky and medicine, decreasing significantly red quality and its commercial value. In this work, cork powder waste was especially prepared and used to remove these negative volatile phenols (4-EP and 4-EG) from spiked red wine. The optimisation of cork powder performance by removal of dichloromethane and ethanol cork extractives, air removal and ethanol impregnation, allowed to obtain 41 to 62% of 4-ethylphenol and 50 to 53% of 4-ethylguaiacol removal from VPs spiked red wine applied at 250 g/hL. There was no significant impact on phenolic acids and monomeric anthocyanins, although being observed a decrease in the headspace aroma abundance (40%). This optimised cork powder allowed to decrease significantly the wine negative phenolic character, bitterness and astringency, recovering the positive fruity and floral sensory attributes. Results show that optimised cork powder can be a good solution for VPs removal, presenting a great potential to be a new oenological fining agent, contributing to the wine industry sustainability.