Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity

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Abstract

Purpose

Vestibulotoxicity associated with cisplatin chemotherapy is known to exist, but the extent, severity, and impact is unclear from the literature. This study explored knowledge, experiences, and opinions of audiovestibular professionals about cisplatin vestibulotoxicity.

Methods

An online survey was disseminated to clinicians working in the audiovestibular field.

Results

Ninety-three respondents participated in the survey. Most professionals were aware of potential vestibulotoxicity associated with cisplatin chemotherapy. Thirty-three percent of the respondents reported that they had seen patients with cisplatin vestibulotoxicity. Forty percent of them were confident in making the diagnosis and in managing the patient in this situation. The prevalence and impact of vestibulotoxicity including practicality of the assessment should be considered when designing an effective vestibulotoxicity screening protocol.

Conclusion

This study provides a better understanding of cisplatin vestibulotoxicity from the perspectives of audiovestibular clinicians, which will underpin appropriate detection and management of the condition.

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Most cited references 32

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A hands-on guide to doing content analysis

Christen Erlingsson, Petra Brysiewicz (2017)

There is a growing recognition for the important role played by qualitative research and its usefulness in many fields, including the emergency care context in Africa. Novice qualitative researchers are often daunted by the prospect of qualitative data analysis and thus may experience much difficulty in the data analysis process. Our objective with this manuscript is to provide a practical hands-on example of qualitative content analysis to aid novice qualitative researchers in their task.

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The Video Head Impulse Test

G M Halmagyi, Luke Chen, Hamish G. MacDougall … (2017)

In 1988, we introduced impulsive testing of semicircular canal (SCC) function measured with scleral search coils and showed that it could accurately and reliably detect impaired function even of a single lateral canal. Later we showed that it was also possible to test individual vertical canal function in peripheral and also in central vestibular disorders and proposed a physiological mechanism for why this might be so. For the next 20 years, between 1988 and 2008, impulsive testing of individual SCC function could only be accurately done by a few aficionados with the time and money to support scleral search-coil systems—an expensive, complicated and cumbersome, semi-invasive technique that never made the transition from the research lab to the dizzy clinic. Then, in 2009 and 2013, we introduced a video method of testing function of each of the six canals individually. Since 2009, the method has been taken up by most dizzy clinics around the world, with now close to 100 refereed articles in PubMed. In many dizzy clinics around the world, video Head Impulse Testing has supplanted caloric testing as the initial and in some cases the final test of choice in patients with suspected vestibular disorders. Here, we consider seven current, interesting, and controversial aspects of video Head Impulse Testing: (1) introduction to the test; (2) the progress from the head impulse protocol (HIMPs) to the new variant—suppression head impulse protocol (SHIMPs); (3) the physiological basis for head impulse testing; (4) practical aspects and potential pitfalls of video head impulse testing; (5) problems of vestibulo-ocular reflex gain calculations; (6) head impulse testing in central vestibular disorders; and (7) to stay right up-to-date—new clinical disease patterns emerging from video head impulse testing. With thanks and appreciation we dedicate this article to our friend, colleague, and mentor, Dr Bernard Cohen of Mount Sinai Medical School, New York, who since his first article 55 years ago on compensatory eye movements induced by vertical SCC stimulation has become one of the giants of the vestibular world.

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Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society

Michael Strupp, Ji-Soo Kim, Toshihisa Murofushi … (2017)

This paper describes the diagnostic criteria for bilateral vestibulopathy (BVP) by the Classification Committee of the Bárány Society. The diagnosis of BVP is based on the patient history, bedside examination and laboratory evaluation. Bilateral vestibulopathy is a chronic vestibular syndrome which is characterized by unsteadiness when walking or standing, which worsen in darkness and/or on uneven ground, or during head motion. Additionally, patients may describe head or body movement-induced blurred vision or oscillopsia. There are typically no symptoms while sitting or lying down under static conditions. The diagnosis of BVP requires bilaterally significantly impaired or absent function of the vestibulo-ocular reflex (VOR). This can be diagnosed for the high frequency range of the angular VOR by the head impulse test (HIT), the video-HIT (vHIT) and the scleral coil technique and for the low frequency range by caloric testing. The moderate range can be examined by the sinusoidal or step profile rotational chair test. For the diagnosis of BVP, the horizontal angular VOR gain on both sides should be <0.6 (angular velocity 150–300°/s) and/or the sum of the maximal peak velocities of the slow phase caloric-induced nystagmus for stimulation with warm and cold water on each side <6°/s and/or the horizontal angular VOR gain <0.1 upon sinusoidal stimulation on a rotatory chair (0.1 Hz, Vmax = 50°/sec) and/or a phase lead >68 degrees (time constant of <5 seconds). For the diagnosis of probable BVP the above mentioned symptoms and a bilaterally pathological bedside HIT are required. Complementary tests that may be used but are currently not included in the definition are: a) dynamic visual acuity (a decrease of ≥0.2 logMAR is considered pathological); b) Romberg (indicating a sensory deficit of the vestibular or somatosensory system and therefore not specific); and c) abnormal cervical and ocular vestibular-evoked myogenic potentials for otolith function. At present the scientific basis for further subdivisions into subtypes of BVP is not sufficient to put forward reliable or clinically meaningful definitions. Depending on the affected anatomical structure and frequency range, different subtypes may be better identified in the future: impaired canal function in the low- or high-frequency VOR range only and/or impaired otolith function only; the latter is evidently very rare. Bilateral vestibulopathy is a clinical syndrome and, if known, the etiology (e.g., due to ototoxicity, bilateral Menière’s disease, bilateral vestibular schwannoma) should be added to the diagnosis. Synonyms include bilateral vestibular failure, deficiency, areflexia, hypofunction and loss.

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Author and article information

Contributors

Pattarawadee Prayuenyong:

ORCID: http://orcid.org/0000-0002-3002-0497

msxpp4@nottingham.ac.uk

Journal

Journal ID (nlm-ta): Eur Arch Otorhinolaryngol

Journal ID (iso-abbrev): Eur Arch Otorhinolaryngol

Title: European Archives of Oto-Rhino-Laryngology

Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )

ISSN (Print): 0937-4477

ISSN (Electronic): 1434-4726

Publication date (Electronic): 19 May 2020

Publication date PMC-release: 19 May 2020

Publication date (Print): 2020

Volume: 277

Issue: 12

Pages: 3283-3293

Affiliations

[1 ]GRID grid.4563.4, ISNI 0000 0004 1936 8868, Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, , University of Nottingham, ; Nottingham, UK

[2 ]NIHR Nottingham Biomedical Research Centre, Ropewalk House, 113 The Ropewalk, Nottingham, UK

[3 ]GRID grid.240404.6, ISNI 0000 0001 0440 1889, Nottingham University Hospitals NHS Trust, ; Nottingham, UK

[4 ]GRID grid.440435.2, University of Nottingham Malaysia, ; Semenyih, Malaysia

[5 ]GRID grid.7130.5, ISNI 0000 0004 0470 1162, Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, , Prince of Songkla University, ; Songkhla, Thailand

Author information

Pattarawadee Prayuenyong http://orcid.org/0000-0002-3002-0497

Anand V. Kasbekar http://orcid.org/0000-0002-0961-8865

Deborah A. Hall http://orcid.org/0000-0002-3804-1452

David M. Baguley http://orcid.org/0000-0002-0767-0723

Article

Publisher ID: 6033

DOI: 10.1007/s00405-020-06033-4

PMC ID: 7648001

PubMed ID: 32430772

SO-VID: 2568acdf-7c43-4477-82cd-236df5cb766b

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 10 January 2020

Date accepted : 1 May 2020

Custom metadata

ScienceOpen disciplines: Otolaryngology

Keywords: audiovestibular,cisplatin,vestibular,vestibulotoxicity

Data availability:

ScienceOpen disciplines: Otolaryngology

Keywords: audiovestibular, cisplatin, vestibular, vestibulotoxicity

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Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity

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Most cited references 32

A hands-on guide to doing content analysis

The Video Head Impulse Test

Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society

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Cited by 1

Most referenced authors 336