RNase1 as a potential mediator of remote ischaemic preconditioning for cardioprotection†.

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Abstract

Remote ischaemic preconditioning (RIPC) is a non-invasive and virtually cost-free strategy for protecting the heart against acute ischaemia-reperfusion injury (IRI). We have recently shown that the inhibition of extracellular RNA (eRNA) using non-toxic RNase1 protected the heart against acute IRI, reduced myocardial infarct (MI) size and preserved left ventricular systolic function in rodent animal MI models. Based on this previous work in animals, the role of the eRNA/RNase1 system in cardiac RIPC in humans should be defined.

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Journal

Journal ID (iso-abbrev): Eur J Cardiothorac Surg

Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

ISSN (Electronic): 1873-734X

ISSN (Print): 1010-7940

Publication date (Electronic): Nov 2015

Volume: 48

Issue: 5

Affiliations

[1 ] Institute of Biochemistry, Medical School, Justus-Liebig-University, Giessen, Germany Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.

[2 ] Department of Cardiovascular Surgery, Medical School, Justus-Liebig-University, Giessen, Germany.

[3 ] Department of Anaesthesia and Intensive Care Medicine, Medical School, Justus-Liebig-University, Giessen, Germany.

[4 ] Department of Cardiovascular Surgery, Medical School, Justus-Liebig-University, Giessen, Germany andreas.boening@chiru.med.uni-giessen.de.

Article

Publisher Item ID: ezu519

DOI: 10.1093/ejcts/ezu519

PubMed ID: 25564211

SO-VID: 248a850e-08bb-4462-80ee-51229d4f4dbd

History

Keywords: Acute inflammation,Cardiac surgery,Extracellular RNA (eRNA),Ischaemia–reperfusion,Remote ischaemic preconditioning,Ribonuclease-1 (RNase1),Tumour necrosis factor-α (TNF-α)

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Keywords: Acute inflammation, Cardiac surgery, Extracellular RNA (eRNA), Ischaemia–reperfusion, Remote ischaemic preconditioning, Ribonuclease-1 (RNase1), Tumour necrosis factor-α (TNF-α)

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