3D asymmetry of operated children with oral clefts

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Abstract

To explore three-dimensional (3D) facial asymmetry differences in operated children with oral clefts and to compare the results with a control group.

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Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder.

P D Sampson, A Streissguth, F L Bookstein … (1997)

We critique published incidences for fetal alcohol syndrome (FAS) and present new estimates of the incidence of FAS and the prevalence of alcohol-related neurodevelopmental disorder (ARND). We first review criteria necessary for valid estimation of FAS incidence. Estimates for three population-based studies that best meet these criteria are reported with adjustment for underascertainment of highly exposed cases. As a result, in 1975 in Seattle, the incidence of FAS can be estimated as at least 2.8/1000 live births, and for 1979-81 in Cleveland, approximately 4.6/1,000. In Roubaix, France (for data covering periods from 1977-1990), the rate is between 1.3 and 4.8/1,000, depending on the severity of effects used as diagnostic criteria. Utilizing the longitudinal neurobehavioral database of the Seattle study, we propose an operationalization of the Institute of Medicine's recent definition of ARND and estimate its prevalence in Seattle for the period 1975-1981. The combined rate of FAS and ARND is thus estimated to be at least 9.1/1,000. This conservative rate--nearly one in every 100 live births--confirms the perception of many health professionals that fetal alcohol exposure is a serious problem.

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The effect of sex and age on facial asymmetry in healthy subjects: a cross-sectional study from adolescence to mid-adulthood.

F. FERRARIO, Chiarella Sforza, C Dellavia … (2001)

The study assessed the effects of sex and age on 3-dimensional (3D) soft-tissue facial asymmetry. The 3D coordinates of selected soft-tissue facial landmarks were digitized on 314 healthy white subjects (40 male and 33 female adolescents, aged 12 to 15 years; 73 female and 89 male young adults, aged 18 to 30 years; and 41 male and 38 female adults, aged 31 to 56 years) by an electromagnetic instrument. Facial asymmetry was quantified by detecting a plane of symmetry and the centers of gravity of the right and left hemifaces and by calculating the distance between the 2 centers of gravity (distance from the symmetry [DFS]). Both absolute (millimeters) and percentage (of the nasion-center of gravity distance) DFS were obtained, as well as the maximum normal asymmetry. The asymmetry of single landmarks was also quantified. No gender- or age-related differences were found for both absolute and percentage DFS (P > .05). The maximum normal asymmetry was slightly greater in females than in males of corresponding age; within each sex, the largest values were found in the adolescent group. Tragion, gonion, and zygion were the most asymmetric landmarks in all groups (about 10% to 12% of the nasion-facial center of gravity distance), whereas the least asymmetric was endocanthion (4% to 6%). A slight soft-tissue facial asymmetry was found in normal subjects. The maximum normal asymmetry could be useful in identifying borderline asymmetric patients.

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A six-center international study of treatment outcome in patients with clefts of the lip and palate: Part 5. General discussion and conclusions.

J McWilliam, C. Roberts, Robert W Shaw … (1992)

Part 5 is the final part of a series of five articles reporting on an international, multicenter clinical audit of treatment outcome for complete UCLP. A number of recommendations for the methodology of future studies is made especially with respect to entry criteria, sample size, assumptions of homogeneity, and the reproducibility and validity of outcome measures. The findings of the present study regarding clinical procedures are presented tentatively, and improvement and extension of the methodology are required. It appears, however, that acceptable results can be achieved by different programs and ultimately clinical choices may be based on factors such as complexity, costs, and demands of treatment. Standardization, centralization, and the participation of high volume operators were associated with good outcomes, and nonstandardization and the participation of low volume operators with poor outcomes. Therapeutic factors associated with good outcomes were the employment of a vomer flap to close the anterior palate, and poor outcomes with primary bone grafting and with active presurgical orthopedics.