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      Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health

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      Trends in Molecular Medicine
      Elsevier BV

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          Abstract

          Environmental effects on the materno-foetal interaction determine birth outcomes that predict health over the lifespan. Thus, maternal undernutrition or stress associate with low birth weight, leading to an increased risk of metabolic and cardiovascular illness in the offspring. We argue that these effects are, in part, mediated by direct and indirect effects on the hypothalamic-pituitary-adrenal (HPA) axis such that (i) the effect of maternal adversity on foetal growth is mediated by adrenal glucocorticoids and (ii) environmental adversity alters maternal physiology and behaviour, which then programs HPA activity in the offspring.

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          Author and article information

          Journal
          Trends in Molecular Medicine
          Trends in Molecular Medicine
          Elsevier BV
          14714914
          July 2007
          July 2007
          : 13
          : 7
          : 269-277
          Article
          10.1016/j.molmed.2007.05.003
          17544850
          2114fb43-a5f9-4df3-ad32-9ae3c4db201a
          © 2007

          https://www.elsevier.com/tdm/userlicense/1.0/

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