Administration of the Hyper-immune Bovine Colostrum Extract IMM-124E Ameliorates Experimental Murine Colitis

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Abstract

<p class="first" id="d5481007e159">Inflammatory bowel disease [IBD] is accompanied by lesions in the epithelial barrier, which allow translocation of bacterial products from the gut lumen to the host's circulation. IMM-124E is a colostrum-based product containing high levels of anti-E.coli-LPS IgG, and might limit exposure to bacterial endotoxins. Here, we investigated whether IMM-124E can ameliorate intestinal inflammation. </p>

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Most cited references 51

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Allan M Mowat, William Agace (2014)

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Author and article information

Journal

Title: Journal of Crohn's and Colitis

Publisher: Oxford University Press (OUP)

ISSN (Print): 1873-9946

ISSN (Electronic): 1876-4479

Publication date Created: June 2019

Publication date Created: May 27 2019

Publication date Created: December 12 2018

Publication date Other: June 2019

Publication date (Print): May 27 2019

Publication date (Electronic): December 12 2018

Volume: 13

Issue: 6

Pages: 785-797

Affiliations

[1 ]Division of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland

[2 ]Immuron Ltd, Melbourne, VIC, Australia

[3 ]Laboratory of Cellular Biophysics, Rockefeller University, New York, NY, USA

[4 ]Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

Article

DOI: 10.1093/ecco-jcc/jjy213

PubMed ID: 30590526

SO-VID: 1fc58af6-f192-4b3c-be10-c2f797e14ebf

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https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

Administration of the Hyper-immune Bovine Colostrum Extract IMM-124E Ameliorates Experimental Murine Colitis

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Abstract

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Behavioral Public Administration

Most cited references 51

Functions of natural killer cells.

Host-bacterial mutualism in the human intestine.

Regional specialization within the intestinal immune system.

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