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Abstract
The clinicopathologic findings in patients with hepatitis C virus (HCV)-related hepatocellular
carcinoma (HCC) positive for biliary markers, those related to the hepatic progenitor
cells, were investigated. Cytokeratin (CK) 19 was reactive for HCCs only in patients
with prior hepatitis B virus (HBV) infection. The proportions of patients with prior
HBV infection and poorly differentiated HCC were significantly higher among those
with CK 19-positive HCC than among those with CK 19-negative HCC. Some HCCs develop
from the hepatic progenitor cells in patients with HCV infection and prior HBV infection,
which may affect the clinicopathologic findings of HCV-related HCCs.