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      Repurposing of Indomethacin and Naproxen as anticancer agents: progress from 2017 to present

      review-article
      a , , a , b
      RSC Advances
      The Royal Society of Chemistry

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          Abstract

          Inflammation is strongly linked to cancer and is essential for the growth and development of tumors. Targeting inflammation and the mediators involved in the inflammatory process could therefore provide a suitable method for cancer prevention and therapy. Numerous studies have shown that inflammation can predispose tumors. Non-steroidal anti-inflammatory drugs (NSAIDs) can affect the tumor microenvironment through increasing apoptosis and chemo-sensitivity while decreasing cell migration. Since the development of novel drugs requires a significant amount of money and time and poses a significant challenge for drug discovery, there has been a recent increase in interest in drug repositioning or repurposing. The growing body of research suggests that drug repurposing is essential for the quicker and less expensive development of anticancer therapies. In order to set the course for potential future repositioning of NSAIDs for clinical deployment in the treatment of cancer, the antiproliferative activity of derivatives of Indomethacin and Naproxen as well as their mechanism of action and structural activity relationships (SARs) published in the time frame from 2017 to 2024 are summarized in this review.

          Abstract

          To aid in potential future repositioning of NSAIDs for cancer treatment, we summarize work from 2017–2024 on the antiproliferative activity of derivatives of indomethacin and naproxen, their mechanism of action and structure–activity relationships.

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          Author and article information

          Journal
          RSC Adv
          RSC Adv
          RA
          RSCACL
          RSC Advances
          The Royal Society of Chemistry
          2046-2069
          23 December 2024
          17 December 2024
          23 December 2024
          : 14
          : 54
          : 40031-40057
          Affiliations
          [a ] Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street, P. O. Box 11562 Cairo Egypt asmaa.kassab@ 123456pharma.cu.edu.eg +2023635140 +2023639307
          [b ] Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC) Badr City, P. O. Box 11829 Cairo Egypt
          Author information
          https://orcid.org/0000-0002-6091-829X
          Article
          d4ra07581a
          10.1039/d4ra07581a
          11664213
          39717807
          180f79fe-610e-48ad-be5a-59c035428e32
          This journal is © The Royal Society of Chemistry

          This article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

          History
          : 23 October 2024
          : 12 December 2024
          Page count
          Pages: 27
          Categories
          Chemistry
          Custom metadata
          Paginated Article

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