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      Natural anti-inflammatory agents for pain relief

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          Abstract

          The use of both over-the-counter and prescription nonsteroidal medications is frequently recommended in a typical neurosurgical practice. But persistent long-term use safety concerns must be considered when prescribing these medications for chronic and degenerative pain conditions. This article is a literature review of the biochemical pathways of inflammatory pain, the potentially serious side effects of nonsteroidal drugs and commonly used and clinically studied natural alternative anti-inflammatory supplements. Although nonsteroidal medications can be effective, herbs and dietary supplements may offer a safer, and often an effective, alternative treatment for pain relief, especially for long-term use.

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          Most cited references113

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          Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

          J R Vane (1971)
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            Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

            The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli. VR1-/- mice showed normal responses to noxious mechanical stimuli but exhibited no vanilloid-evoked pain behavior, were impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation. Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.
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              The vanilloid receptor: a molecular gateway to the pain pathway.

              The detection of painful stimuli occurs primarily at the peripheral terminals of specialized sensory neurons called nociceptors. These small-diameter neurons transduce signals of a chemical, mechanical, or thermal nature into action potentials and transmit this information to the central nervous system, ultimately eliciting a perception of pain or discomfort. Little is known about the proteins that detect noxious stimuli, especially those of a physical nature. Here we review recent advances in the molecular characterization of the capsaicin (vanilloid) receptor, an excitatory ion channel expressed by nociceptors, which contributes to the detection and integration of pain-producing chemical and thermal stimuli. The analysis of vanilloid receptor gene knockout mice confirms the involvement of this channel in pain sensation, as well as in hypersensitivity to noxious stimuli following tissue injury. At the same time, these studies demonstrate the existence of redundant mechanisms for the sensation of heat-evoked pain.
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                Author and article information

                Journal
                Surg Neurol Int
                SNI
                Surgical Neurology International
                Medknow Publications (India )
                2229-5097
                2152-7806
                2010
                13 December 2010
                : 1
                : 80
                Affiliations
                Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
                [1 ]Vanderbilt University, Nashville, TN, USA
                Author notes
                *Corresponding author
                Article
                SNI-1-80
                10.4103/2152-7806.73804
                3011108
                21206541
                16b4afe4-187a-48eb-ac36-f9ed51d06eb8
                © 2010 Maroon JC

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 20 October 2010
                : 22 October 2010
                Categories
                Review Article

                Surgery
                inflammation,natural anti-inflammatories,pain,alternative treatments
                Surgery
                inflammation, natural anti-inflammatories, pain, alternative treatments

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