Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

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Abstract

Understanding molecular mechanisms of response and resistance to anticancer therapies requires prospective patient follow-up and clinical and functional validation of both common and low-frequency mutations. We describe a whole-exome sequencing (WES) precision medicine trial focused on patients with advanced cancer.

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Author and article information

Journal

Title: JAMA Oncology

Abbreviated Title: JAMA Oncol

Publisher: American Medical Association (AMA)

ISSN (Print): 2374-2437

Publication date Created: July 01 2015

Publication date (Print): July 01 2015

Volume: 1

Issue: 4

Page: 466

Affiliations

[1 ]Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medical College, New York, New York2Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, New York3Department of Medicine, Weill Cornell Medical

[2 ]Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medical College, New York, New York4Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York

[3 ]Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medical College, New York, New York5Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York

[4 ]Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medical College, New York, New York

[5 ]Centre of Integrative Biology, University of Trento, Trento, Italy

[6 ]Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York

[7 ]Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, New York

[8 ]Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada

[9 ]New York Genome Center, New York, New York

[10 ]Department of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York

[11 ]Department of Radiology, Weill Cornell Medical College, New York, New York

[12 ]Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York11Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York

[13 ]Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medical College, New York, New York6Centre of Integrative Biology, University of Trento, Trento, Italy

[14 ]Rockefeller University, New York, New York

[15 ]Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York6Centre of Integrative Biology, University of Trento, Trento, Italy

[16 ]Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medical College, New York, New York4Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York5Department of Pathology and Laboratory Medicine,

Article

DOI: 10.1001/jamaoncol.2015.1313

PubMed ID: 26181256

SO-VID: 147081f7-1ef3-428c-9301-01449aa827de

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